Systematic review of the safety of topical corticosteroids in pregnancy

Journal of the American Academy of Dermatology
Ching-Chi ChiF Wojnarowska

Abstract

Pregnant women may have skin conditions that require topical corticosteroids. However, little is known about their safety in pregnancy. We sought to evaluate the available evidence concerning the safety of topical corticosteroids in pregnancy. We systematically searched 17 databases and trial registers, and contacted pharmaceutical companies. Randomized controlled trials and cohort studies of topical corticosteroids in pregnant women, and case-control studies comparing maternal exposure to topical corticosteroids between patients and control subjects were included. The Newcastle-Ottawa Scale was used for quality assessment of included studies. Seven studies, including two cohort and five case-control studies, were included. Most studies did not find significant associations of topical corticosteroids with congenital abnormality, preterm delivery stillbirth, and mode of delivery. One study found a significant association between first-trimester use of topical corticosteroids and orofacial cleft, and another study found a significant association between very potent topical corticosteroids and low birthweight. The available data were limited and mainly on orofacial cleft. The quality of evidence was generally low. Currently limite...Continue Reading

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Citations

Nov 25, 2011·Obstetrical & Gynecological Survey·Ioannis KoutroulisGeorge Kroumpouzos
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