Systematic Review with Meta-Analysis: Concomitant Therapy vs. Triple Therapy for the First-Line Treatment of Helicobacter pylori Infection

The American Journal of Gastroenterology
Mei-Jyh ChenTaiwan Gastrointestinal Disease Helicobacter Consortium

Abstract

Whether concomitant therapy is superior to triple therapy of various treatment lengths for the first-line treatment of H. pylori remains controversial. The objective of this study is to compare the efficacy of concomitant therapy and triple therapy given for 5-14 days. Randomized control trials (RCTs) comparing the efficacy of concomitant therapy for 5-14 days and proton pump inhibitor-amoxicillin-clarithromycin (PAC)-based triple therapy for 5-14 days in the first-line treatment of adult patients with H. pylori infection published from 1990 to January 2018 were searched from the PubMed, Cochrane Library, and Embase. Abstracts from international annual conferences were also searched. The primary and secondary outcomes were the eradication rate according to the intention-to-treat analysis and the adverse effects, respectively. Subgroup analyses were also performed according to treatment length. This study is registered with PROSPERO, number CRD42017081328. Of the 639 articles identified, 23 RCTs including 3305 patients in the concomitant therapy group and 3327 patients in the triple therapy group were eligible. Overall, concomitant therapy was superior to triple therapy [risk ratio (RR): 1.15; 95% confidence interval (CI): 1.09-...Continue Reading

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Citations

Jan 28, 2020·Journal of Gastroenterology and Hepatology·Jyh-Ming LiouMing-Shiang Wu
Jul 7, 2020·Middle East Journal of Digestive Diseases·Zohreh BariMohammad Yaghoobi
Oct 5, 2018·Journal of Biomedical Science·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
May 16, 2019·World Journal of Gastroenterology : WJG·Sho SuzukiTakuji Gotoda
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Jul 29, 2020·Antibiotics·Su Young Kim, Jun-Won Chung
Jul 24, 2020·Minerva medica·Rocco M ZagariFranco Bazzoli
Jun 18, 2021·Expert Review of Vaccines·Irineu Dos Santos VianaFabrício Freire de Melo
Mar 31, 2021·Gut and Liver·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium

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