Systematic Search for Evidence of Interdomain Horizontal Gene Transfer from Prokaryotes to Oomycete Lineages

Charley G P McCarthy, David A Fitzpatrick


While most commonly associated with prokaryotes, horizontal gene transfer (HGT) can also have a significant influence on the evolution of microscopic eukaryotes. Systematic analysis of HGT in the genomes of the oomycetes, filamentous eukaryotic microorganisms in the Stramenopiles-Alveolates-Rhizaria (SAR) supergroup, has to date focused mainly on intradomain transfer events between oomycetes and fungi. Using systematic whole-genome analysis followed by phylogenetic reconstruction, we have investigated the extent of interdomain HGT between bacteria and plant-pathogenic oomycetes. We report five putative instances of HGT from bacteria into the oomycetes. Two transfers were found in Phytophthora species, including one unique to the cucurbit pathogen Phytophthora capsici. Two were found in Pythium species only, and the final transfer event was present in Phytopythium and Pythium species, the first reported bacterium-inherited genes in these genera. Our putative transfers included one protein that appears to be a member of the Pythium secretome, metabolic proteins, and enzymes that could potentially break down xenobiotics within the cell. Our findings complement both previous reports of bacterial genes in oomycete and SAR genomes an...Continue Reading


Apr 1, 1992·Protein Engineering·D L OllisJ Schrag
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 20, 1998·Bioinformatics·J O McInerney
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·R JainJ A Lake
May 12, 2000·Plant Physiology·D QutobM Gijzen
May 29, 2000·Trends in Genetics : TIG·P RiceA Bleasby
Jul 13, 2000·Journal of Molecular Biology·O EmanuelssonG von Heijne
Feb 13, 2001·Metabolic Engineering·W R Strohl
Mar 7, 2001·Molecular Biology and Evolution·L B KoskiG B Golding
Jul 27, 2001·Molecular Biology and Evolution·D GerbodE Viscogliosi
May 22, 2002·Protein Science : a Publication of the Protein Society·Marcel EstévezTodd M Weaver
Nov 9, 2002·Bioinformatics·Kevin HoweRichard Durbin
Sep 4, 2003·Genome Research·Paul D ThomasApurva Narechania
Sep 4, 2003·Genome Research·Li LiDavid S Roos
Oct 8, 2003·Systematic Biology·Stéphane Guindon, Olivier Gascuel
Jan 22, 2004·Nature Reviews. Genetics·Jeremy N TimmisWilliam Martin
Apr 6, 2004·Current Opinion in Chemical Biology·Dick B Janssen
Oct 2, 2004·Science·E Virginia ArmbrustDaniel S Rokhsar
Mar 11, 2005·Mycological Research·C André Lévesque, Arthur W A M de Cock
Aug 12, 2005·Cytogenetic and Genome Research·J JurkaJ Walichiewicz
Oct 14, 2005·Molecular Biology and Evolution·Daniel H Huson, David Bryant
Apr 7, 2006·Applied and Environmental Microbiology·Bert van LooDick B Janssen
Sep 19, 2006·Current Biology : CB·Thomas A RichardsNicholas J Talbot
Jan 26, 2007·Nature·Nigel Goldenfeld, Carl Woese
Aug 30, 2007·PloS One·Fabien BurkiJan Pawlowski
Sep 27, 2007·BMC Evolutionary Biology·Tetyana Nosenko, Debashish Bhattacharya
Dec 12, 2007·Reviews of Environmental Contamination and Toxicology·John E ThomasAbid All-Agely
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cindy MartensYves Van de Peer
Jul 2, 2008·Nature Reviews. Genetics·Patrick J Keeling, Jeffrey D Palmer
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tal DaganWilliam Martin
Oct 17, 2008·Nature·Chris BowlerIgor V Grigoriev
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vladimir HamplAndrew J Roger
Dec 9, 2009·Trends in Genetics : TIG·Marina Marcet-Houben, Toni Gabaldón
Dec 17, 2009·BMC Bioinformatics·Christiam CamachoThomas L Madden
Mar 17, 2010·Nature·Jarrod A ChapmanRobert E Steele
May 4, 2010·Applied and Environmental Microbiology·Michele T Hoffman, A Elizabeth Arnold

❮ Previous
Next ❯


Mar 16, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michelle M LegerAndrew J Roger
Dec 5, 2017·MSphere·Jamie McGowan, David A Fitzpatrick
Dec 13, 2017·Frontiers in Immunology·Aaron LernerRustam Aminov
Apr 25, 2017·MSphere·Charley G P McCarthy, David A Fitzpatrick
Feb 5, 2019·Microbial Genomics·Charley G P McCarthy, David A Fitzpatrick
Mar 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·David S MilnerThomas A Richards
May 16, 2017·Annual Review of Microbiology·Howard S Judelson

❮ Previous
Next ❯

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.