Systematic Search for Evidence of Interdomain Horizontal Gene Transfer from Prokaryotes to Oomycete Lineages

MSphere
Charley G P McCarthy, David A Fitzpatrick

Abstract

While most commonly associated with prokaryotes, horizontal gene transfer (HGT) can also have a significant influence on the evolution of microscopic eukaryotes. Systematic analysis of HGT in the genomes of the oomycetes, filamentous eukaryotic microorganisms in the Stramenopiles-Alveolates-Rhizaria (SAR) supergroup, has to date focused mainly on intradomain transfer events between oomycetes and fungi. Using systematic whole-genome analysis followed by phylogenetic reconstruction, we have investigated the extent of interdomain HGT between bacteria and plant-pathogenic oomycetes. We report five putative instances of HGT from bacteria into the oomycetes. Two transfers were found in Phytophthora species, including one unique to the cucurbit pathogen Phytophthora capsici. Two were found in Pythium species only, and the final transfer event was present in Phytopythium and Pythium species, the first reported bacterium-inherited genes in these genera. Our putative transfers included one protein that appears to be a member of the Pythium secretome, metabolic proteins, and enzymes that could potentially break down xenobiotics within the cell. Our findings complement both previous reports of bacterial genes in oomycete and SAR genomes an...Continue Reading

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Citations

Mar 16, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michelle M LegerAndrew J Roger
Dec 5, 2017·MSphere·Jamie McGowan, David A Fitzpatrick
Dec 13, 2017·Frontiers in Immunology·Aaron LernerRustam Aminov
Apr 25, 2017·MSphere·Charley G P McCarthy, David A Fitzpatrick
Feb 5, 2019·Microbial Genomics·Charley G P McCarthy, David A Fitzpatrick
Mar 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·David S MilnerThomas A Richards
May 16, 2017·Annual Review of Microbiology·Howard S Judelson

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Software Mentioned

OrthoMCL
BLAST
tBLASTn
BLASTp
SignalP
TargetP
GCUA
PhyML
iTOL
ProtTest

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