Abstract
Self-assembling cyclic peptides (CP) consisting of amino acids with alternating d- and l-chirality form nanotubes by hydrogen bonding, hydrophobic interactions, and π-π stacking in solution. These highly dynamic materials are emerging as promising supramolecular systems for a wide range of biomedical applications. Herein, we discuss how varying the polymer conformation (linear vs. brush), as well as the number of polymer arms per peptide unimer affects the self-assembly of PEGylated cyclic peptides in different solvents, using small angle neutron scattering. Using the derived information, strong correlations were drawn between the size of the aggregates, solvent polarity, and its ability to compete for hydrogen bonding interactions between the peptide unimers. Using these data, it could be possible to engineer cyclic peptide nanotubes of a controlled length.
References
May 26, 1994·Nature·M R GhadiriL K Buehler
Nov 25, 1993·Nature·M R GhadiriN Khazanovich
May 12, 2001·The Journal of Organic Chemistry·M H Abraham, J A Platts
Jul 27, 2001·Nature·S Fernandez-LopezM R Ghadiri
Apr 15, 2005·Angewandte Chemie·Julien CouetMarkus Biesalski
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Véronique DartoisThomas R Parr
Oct 26, 2005·Drug Discovery Today·Francesco M Veronese, Gianfranco Pasut
May 16, 2007·The Biochemical Journal·Jörg AndräKlaus Brandenburg
Jun 26, 2008·Small·Julien Couet, Markus Biesalski
Mar 20, 2009·Journal of Chemical Information and Modeling·Johannes SchwöbelGerrit Schüürmann
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Nov 26, 2011·Nanoscale·Mordechay MizrahiNurit Ashkenasy
Aug 10, 2012·Chemical Society Reviews·Robert ChapmanSébastien Perrier
Jun 15, 2013·Chemical Communications : Chem Comm·Robert ChapmanSébastien Perrier
Nov 5, 2013·Soft Matter·Dindyal MandalKeykavous Parang
Nov 14, 2013·Nature Communications·Maarten DanialKatrina A Jolliffe
Mar 22, 2014·Soft Matter·Luis Ruiz, Sinan Keten
May 9, 2014·Journal of the American Chemical Society·Maarten DanialSébastien Perrier
May 14, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ruth Duncan
Aug 26, 2014·Chemistry : a European Journal·Bianca M BlundenMartina H Stenzel
Mar 5, 2016·The Journal of Physical Chemistry. B·Ari Benjamin, Sinan Keten
Nov 15, 2016·Nanoscale·Dan MaSinan Keten
Apr 5, 2017·Organic & Biomolecular Chemistry·N Rodríguez-VázquezJ R Granja
Jun 6, 2017·Chemical Communications : Chem Comm·Mitchell R SilkDavid K Chalmers
Nov 21, 2017·Biomacromolecules·Sophie C LarnaudieSébastien Perrier
Citations
Nov 13, 2018·Macromolecular Rapid Communications·Shuaiyuan HanLaurent Bouteiller
Oct 20, 2018·Chemistry : a European Journal·Huda ShaikhSebastien Perrier
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shabnam TarvirdipourCornelia G Palivan
Apr 30, 2020·Chemical Communications : Chem Comm·Franka V GruschwitzJohannes C Brendel
Jul 12, 2019·Chemical Science·Matthias HartliebSébastien Perrier
Oct 19, 2019·Nature Communications·Julia Y RhoSébastien Perrier
Dec 23, 2020·Biomacromolecules·Sean H EllacottSébastien Perrier
May 4, 2021·Chemical Reviews·Qiao SongSébastien Perrier