Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

Organic & Biomolecular Chemistry
Akihiro KasaiKazunobu Toshima

Abstract

Low-molecular weight type I and II fucoidan derivatives with different sulfation patterns were designed and systematically synthesized from the corresponding common key intermediate and their anti-proliferative activities and apoptosis-inducing activities against human breast cancer (MCF-7) and human cervical epithelioid carcinoma (HeLa) cells were evaluated. Our results demonstrated that one of the type II fucoidan derivatives, 9, effectively reduced the number of viable MCF-7 and HeLa cells in a dose-dependent manner without causing cytotoxicity toward normal WI-38 cells, and that the anti-proliferative activity of 9 was comparable to that of fucoidan 2 isolated from Fucus vesiculosus. Moreover, it was found that both 2 and 9 exhibited similar apoptosis-inducing activities through activation of caspase-8 and -9 on MCF-7 and HeLa cells, respectively.

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Citations

Aug 3, 2016·Marine Drugs·Lucas CholletFrédéric Chaubet
Jun 20, 2018·Chemical Communications : Chem Comm·Shuhei KosonoKazunobu Toshima
Jan 10, 2019·Marine Drugs·Geert van WeeldenJohanna M A Pijnenborg
Aug 24, 2019·Marine Drugs·Sibusiso LuthuliHaibin Tong
May 2, 2019·Clinical and Translational Medicine·Hsien-Yeh Hsu, Pai-An Hwang
Nov 16, 2017·Molecular Medicine Reports·Minghao NieXiurong Li
Mar 22, 2020·Marine Drugs·Ahmed Zayed, Roland Ulber
Dec 21, 2016·Macromolecular Bioscience·Catarina OliveiraTiago H Silva
Aug 1, 2018·Marine Drugs·Marcelo D CatarinoSusana M Cardoso
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Murugesan Sathiya DeepikaRamasamy Thirumurugan
Jun 17, 2021·Critical Reviews in Food Science and Nutrition·Xiaomin ZhangChanghu Xue
Aug 10, 2017·Chemical Reviews·Christine KinnaertMads H Clausen

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