Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats

Brain Research Bulletin
C V BorlonganP R Sanberg

Abstract

Previous animal studies have demonstrated that systemic administration of 3-nitropropionic acid (3-NP) leads to neuropathological changes similar to those seen in Huntington's disease (HD). Recently, we reported hypoactivity in 6- and 10-week old rats treated with systemic 3-NP (IP, 10 mg/kg/day) once every 4 days for 28 days. Although these behavioral results seem to differ from the observed hyperactivity in most excitotoxic models of HD, 3-NP may provide a better model of juvenile onset and advanced HD. In the present study, older rats were similarly treated with 3-NP to further characterize the reported age dependency of striatal neuronal death caused by 3-NP. Hypoactivity was observed in 14- and 28-week old rats with the latter demonstrating more profound features. The present study also provided the first direct evidence of a 3-NP effect on passive avoidance behavior. Experimental and control animals showed no significant difference in daytime acquisition and retention of a passive avoidance task. However, when the retention tests were conducted during the night time (in contrast to previous daytime tests), 3-NP-treated animals exhibited significant retention deficits. In addition, the neuropathological effects of 3-NP wer...Continue Reading

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Citations

Nov 1, 1995·Physiology & Behavior·C V BorlonganP R Sanberg
Jan 1, 1997·Neuroscience and Biobehavioral Reviews·C V BorlonganP R Sanberg
May 1, 1997·Neuroscience and Biobehavioral Reviews·C V BorlonganP R Sanberg
Oct 9, 1999·Progress in Neurobiology·E BrouilletP Hantraye
Mar 4, 2000·Neuroscience Letters·S G Poulos, C V Borlongan
Aug 1, 1997·Brain Research. Brain Research Protocols·C V BorlonganP R Sanberg
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Jul 1, 1997·Brain Pathology·C L WellingtonM R Hayden
Aug 11, 2011·Neurochemistry International·Heba M MahdyAmani E Khalifa
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Feb 1, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ashish DhirS K Kulkarni
Aug 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Regina H SilvaRoberto Frussa-Filho
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Jun 18, 2005·Brain Research·Akihiko HoshiTeiji Yamamoto
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Mar 23, 2007·European Journal of Pharmacology·Dariusz PogockiElzbieta Wałajtys-Rode
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May 1, 2001·The International Journal of Neuroscience·S Rivas-ArancibiaP R Sanberg

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