PMID: 9416714Jan 7, 1998Paper

Systemic absorption and block after epidural injection of ropivacaine in healthy volunteers

Anesthesiology
B M EmanuelssonL L Gustafsson

Abstract

For local anesthetics, the process of removal from the site of administration influences the duration of anesthesia and the risk for systemic toxicity to develop. The systemic absorption of epidural ropivacaine and the time profile of sensory and motor block were studied in healthy volunteers. Nine persons simultaneously received 150 mg ropivacaine hydrochloride (7.5 mg/ml) epidurally and 40 mg deuterium-labeled (2H3)ropivacaine hydrochloride (0.25 mg/ml) intravenously. Peripheral arterial and venous plasma samples were collected, and assessments of sensory and motor block were made. The arterial plasma concentrations increased faster than the venous concentrations, with 50% higher maximum concentrations after both intravenous and epidural administration. The absorption was biphasic. A correlation was seen between the duration of sensory block and the slower absorption half-life; that is, the longer the half-life, the longer the duration. The extent of spread varied among the volunteers, with the median upper block level not exceeding T12. The motor block (Bromage score 1) was of slower onset (median, 0.4 h) and of shorter duration (median, 4.1 h) than the sensory block (onset, 0.2 h; duration, 6.5 h at L2 medians). As much as ...Continue Reading

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Citations

Nov 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A N SandlerD Muzyka
Sep 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P H MakM G Irwin
Nov 17, 2010·European Journal of Clinical Pharmacology·Maria CusatoMario Regazzi
Jul 20, 2007·Archives of Gynecology and Obstetrics·Masashi YoshidaKenichi Furuya
Feb 9, 2000·Pharmacology & Therapeutics·N J O'Keeffe, T E Healy
Jan 22, 2003·British Journal of Clinical Pharmacology·Eva ArlanderLars L Gustafsson
Mar 29, 2000·Paediatric Anaesthesia·W HabreC Sims
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Feb 28, 2001·Anesthesia and Analgesia·A JuncaF Bonnet
Aug 25, 2007·Anesthesia and Analgesia·François-Xavier RosePascal Le Corre
Jan 13, 2004·Clinical Pharmacokinetics·Jean-Xavier Mazoit, Bernard J Dalens
Jun 29, 2006·Clinical Pharmacokinetics·Andrea N EdgintonStefan Willmann
Apr 18, 2014·Indian Journal of Pharmacology·Hanene EljebariAnis Klouz
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Jul 23, 2005·Journal of Neurosurgical Anesthesiology·Paul B AuduDavid Andrews
Oct 3, 2006·Current Opinion in Anaesthesiology·L E Mather, S R Edwards
Oct 6, 2006·Current Opinion in Anaesthesiology·Jane M Peutrell, Per-Arne Lonnqvist
Jul 28, 2004·Anesthesiology·Hideyuki HiguchiTomiei Kazama
Jan 2, 2007·Anesthesiology·Mika J JokinenKlaus T Olkkola
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Oct 20, 2007·Acta Anaesthesiologica Scandinavica·P L LinC H Huang
Jun 22, 2005·Best Practice & Research. Clinical Anaesthesiology·Mika J Jokinen
Jun 8, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yang ZhouGuang-Hua Lei
Nov 7, 2000·British Journal of Anaesthesia·P A LönnqvistM Bielenstein
Dec 6, 2001·British Journal of Anaesthesia·D WiedemannW Röse
Sep 28, 2001·Anesthesia and Analgesia·M E McCannC B Berde

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