Systemic Activation of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder

International Journal of Molecular Sciences
Toshifumi Sugatani

Abstract

The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in part by the CKD-mineral bone disorder (CKD-MBD) syndrome. The CKD-MBD consists of skeletal, vascular and cardiac pathology caused by metabolic derangements produced by kidney disease. The prevalence of osteopenia/osteoporosis resulting from the skeletal component of the CKD-MBD, renal osteodystrophy (ROD), in patients with CKD exceeds that of the general population and is a major public health concern. That CKD is associated with compromised bone health is widely accepted, yet the mechanisms underlying impaired bone metabolism in CKD are not fully understood. Therefore, clarification of the molecular mechanisms by which CKD produces ROD is of crucial significance. We have shown that activin A, a member of the transforming growth factor (TGF)-β super family, is an important positive regulator of receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis with Smad-mediated signaling being crucial for inducing osteoclast development and function. Recently, we have demonstrated systemic activation of activin receptors and activin A levels in CKD mouse models, such as diabetic CKD and Alport (AL) syndrome. In these...Continue Reading

References

Aug 31, 1992·Biochemical and Biophysical Research Communications·R YamadaM Muramatsu
Oct 1, 1992·The Journal of Clinical Investigation·B F BoyceG R Mundy
Dec 24, 1992·Nature·Z Q WangE F Wagner
Feb 1, 1992·Endocrine Reviews·T SudaT J Martin
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerK Nikolics
Aug 31, 1993·Biochemical and Biophysical Research Communications·R SakaiH Shinoda
Nov 1, 1994·Calcified Tissue International·S InoueM Muramatsu
Mar 23, 1995·Nature·M M MatzukA Bradley
Jan 1, 1996·Gerontology·T HosoiH Orimo
Mar 6, 1997·Nature·M M TondraviS L Teitelbaum
Jul 2, 1998·Biochemical and Biophysical Research Communications·A MizunoH Ozawa
Dec 8, 1998·Nature Genetics·F LiuA Ruiz i Altaba
Dec 16, 1998·European Journal of Endocrinology·P LoriaN Carulli
Jan 5, 1999·The Journal of Biological Chemistry·K YagiK Miyazono
Jan 8, 1999·Biochemical and Biophysical Research Communications·N NakagawaK Higashio
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HsuW J Boyle
Sep 29, 1999·Genes & Development·W C DougallJ Schuh
Feb 1, 2000·Biochemical and Biophysical Research Communications·K FullerT J Chambers
Apr 25, 2000·The EMBO Journal·J Massagué, D Wotton
Feb 13, 2001·Nucleic Acids Research·Z A QuinnJ C McDermott

❮ Previous
Next ❯

Citations

Aug 30, 2019·Seminars in Dialysis·Elijah KakaniAmr El-Husseini
Jun 4, 2020·Journal of Clinical Medicine·Karolina WoziwodzkaKatarzyna Krzanowska
Jul 19, 2020·Journal of Clinical Medicine·Wilfried Gyselaers
Sep 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giuseppe CiancioloMario Cozzolino
Apr 29, 2019·Journal of Nephrology·Baris AfsarMehmet Kanbay
Jun 27, 2019·Pflügers Archiv : European journal of physiology·Anders NordholmEwa Lewin
Aug 28, 2021·Cells·Pasquale EspositoGiacomo Garibotto

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
immunoprecipitation
ChIP-seq
transgenic
ChIP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthritis Research & Therapy
Michelle FennenBerno Dankbar
Clinical and Experimental Pharmacology & Physiology
Yu-Si ChenTie-Jian Jiang
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Wei Ling LauCecilia M Giachelli
Advances in Chronic Kidney Disease
Anca Gal-Moscovici, Stuart M Sprague
© 2022 Meta ULC. All rights reserved