PMID: 6965228Jan 1, 1982Paper

Systemic activation of macrophages by liposome-entrapped muramyl tripeptide in mice pretreated with the chemotherapeutic agent adriamycin

Cancer Immunology, Immunotherapy : CII
G Hisano, I J Fidler

Abstract

The purpose of these studies was to determine whether macrophages of mice pretreated with the chemotherapeutic agent adriamycin (ADR) could be systemically activated by IV injection of liposomes containing muramyl tripeptide phosphatidylethanolamine (MTP-PE), a lipophilic derivative of muramyl dipeptide. Lower than normal levels of alveolar macrophages or peritoneal exudate macrophages were found in mice following IV injection of ADR. This decrease was dose-dependent and, in mice given less than 10 mg ADR/kg, it was transient (14 days). Peritoneal macrophages surviving the administration of 15 mg ADR/kg were tumoricidal. At various times after single or repeated administration of ADR, mice were given IV or IP injections of liposomes containing MTP-PE. One day thereafter, the cytotoxic activity of the in situ-activated macrophages (alveolar or peritoneal exudate) was assessed in culture against syngeneic melanoma cells. Our data demonstrate that under defined conditions the systemic administration of ADR does not interfere with the in situ activation of tumoricidal properties of murine macrophages after IV injection of liposomes containing a macrophage-activating agent.

Citations

Feb 1, 1990·Cancer Metastasis Reviews·P W WhitworthI J Fidler
Jan 1, 1985·Springer Seminars in Immunopathology·F SpreaficoA Montovani
Sep 12, 2015·Medicinal Research Reviews·Zhiyan XiaoKuo-Hsiung Lee
Apr 1, 1984·Medicinal Research Reviews·A Adam, E Lederer
Aug 13, 2009·Expert Review of Anticancer Therapy·Paul A Meyers
May 8, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chand KhannaMark Bernstein

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