Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient

Neuropediatrics
C M KrammS Burdach

Abstract

During ganciclovir treatment of an adolescent ependymoma patient two weeks after intracranial implantation of HSVtk retroviral vector producer cells, increasing numbers of peripheral T- and B-cells were found as well as enhanced T-cell activation and elevated serum levels of interleukin 12 and soluble Fas ligand. These findings suggest the systemic activation of the immune system during ganciclovir treatment in our patient. The induction of an immune response by HSVtk/ganciclovir supports the concept of an anti-tumor vaccination effect by prodrug activating gene therapy systems and may open new promising perspectives for enhancing therapeutic efficiency by combined prodrug activating and immunological gene therapy strategies.

Citations

Jun 2, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M SangraC Mallucci
Feb 22, 2002·Critical Reviews in Oncology/hematology·S Burdach, H Jürgens
Sep 4, 2003·The Cancer Journal·Nikolai G Rainov, Huan Ren
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobuyuki HinataAkinobu Gotoh
Aug 4, 2015·Neurosurgical Focus·Michael KarsyMark A Mahan

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