Systemic Acute-phase Response in Laparoscopic and Open Ileal Pouch Anal Anastomosis in Patients With Ulcerative Colitis: A Case-matched Comparative Study

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Yoshiki OkitaMasato Kusunoki

Abstract

The current trial was designed to study and compare the postoperative outcomes and systemic acute responses between patients undergoing laparoscopic-ileal pouch anal anastomosis (LAP-IPAA) and open IPAA for ulcerative colitis. The clinical records of patients who underwent 89 restorative proctocolectomy procedures with IPAA were reviewed. After determining which patients underwent LAP-IPAA versus open IPAA, an equivalent number of controls matched for age and ulcerative colitis severity were selected. Twenty of 22 patients who underwent laparoscopic surgery met the inclusion criteria. Patients who underwent LAP-IPAA had significantly shorter times to first walking (P=0.021) and food intake (P=0.0003). The LAP-IPAA group had significantly lower interleukin-6 and interleukin-1ra levels soon after surgery (P=0.011 and P=0.0076). The LAP-IPAA group had significantly lower C-reactive protein levels on postoperative day 1 (P=0.0027). LAP-IPAA is a less-invasive operative procedure than open IPAA with respect to the postoperative systemic inflammatory response and postoperative recovery.

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Aug 1, 1995·Annals of Surgery·V W FazioT K Schroeder
Aug 1, 1994·Diseases of the Colon and Rectum·G D HarmonM J Warzynski
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
May 18, 2001·Diseases of the Colon and Rectum·S DelgadoJ Visa
Oct 29, 1955·British Medical Journal·S C TRUELOVE, L J WITTS
May 12, 2004·Surgical Endoscopy·M BuunenN D Bouvy
Mar 31, 2011·World Journal of Gastroenterology : WJG·Hermann KesslerWerner Hohenberger
Sep 8, 2011·Surgical Endoscopy·Konstantinos E TsimogiannisGeorge Basdanis
Feb 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Léon Maggiori, Yves Panis
Apr 9, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P SinghP Tekkis

❮ Previous
Next ❯

Citations

Nov 11, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Fábio Guilherme CamposIvan Cecconello

❮ Previous
Next ❯

Methods Mentioned

BETA
ileal
dissection
ELISA

Software Mentioned

JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.