Abstract
Cell-assisted lipotransfer, a technique involving free fat grafting mixed with adipose-derived stromal cells, has gained popularity for enhancing fat graft retention. In terms of stem cell delivery, intravenous injection can be a novel alternative with clinical value. However, the effects of intravenously injected adipose-derived stromal cells concurrent with fat grafting have not been described. The authors investigated the histologic and microenvironmental changes in grafted fat when adipose-derived stromal cells were injected intravenously concurrent with grafting. Using a modified animal model of cell-assisted lipotransfer, adipose tissue from green fluorescent protein-expressing C57BL/6J (B6) mice was grafted into recipient wild-type B6 mice, followed by intravenous injection of adipose-derived stromal cells from DsRed-expressing B6 mice. The distribution of adipose-derived stromal cells was evaluated using bioluminescent imaging, and graft volume was measured using micro-computed tomographic scans. Donor fat and adipose-derived stromal cells were traced using immunofluorescent staining. The authors identified the recruitment of adipose-derived stromal cells inside the graft after intravenous injection of adipose-derived s...Continue Reading
References
Jun 1, 1997·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·D L CrandallJ G Kral
Mar 23, 1999·Nature Medicine·E M HorwitzM K Brenner
Feb 16, 2002·European Heart Journal·T SkoogA Hamsten
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maria A RupnickM Judah Folkman
Mar 18, 2003·Transplantation·Gordon D WuDonald V Cramer
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Dec 23, 2008·Stem Cells and Development·Uwe M FischerCharles S Cox
Feb 1, 1945·The Journal of Experimental Medicine·I Gersh, M A Still
Jun 8, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Oct 23, 2010·Molecular Cell·Amar J MajmundarM Celeste Simon
Apr 22, 2011·Lab Animal·Tal YardeniShelley Hoogstraten-Miller
May 3, 2012·The Journal of Sexual Medicine·Xuefeng QiuChing-Shwun Lin
Apr 5, 2013·PloS One·Gregory V GoldmacherLorraine Iacovitti
Aug 19, 2014·Journal of Hepato-biliary-pancreatic Sciences·Yu SaitoChie Takasu
Mar 19, 2015·Journal of Feline Medicine and Surgery·Jessica M QuimbySteve W Dow
Apr 2, 2015·Clinics in Plastic Surgery·Takanobu Mashiko, Kotaro Yoshimura
Apr 2, 2015·Clinics in Plastic Surgery·Shinichiro Kuno, Kotaro Yoshimura
Jun 5, 2016·Cytotherapy·Yong Zhao, Haiyang Zhang
Jun 20, 2017·The Journal of Trauma and Acute Care Surgery·Barbara A ChristyAndrew P Cap
Nov 4, 2017·Scientific Reports·Takuya KotaniMasaaki Ii
Feb 28, 2018·Plastic and Reconstructive Surgery·Joon Pio HongPeter Hyunsuk Suh
Mar 20, 2018·Annals of Plastic Surgery·Hak ChangKi Yong Hong
Citations
Sep 7, 2019·Plastic and Reconstructive Surgery·Ki Yong HongHak Chang
Sep 7, 2019·Plastic and Reconstructive Surgery·Shengyang Jin, Facheng Li
Dec 14, 2019·Plastic and Reconstructive Surgery·Ki Yong HongHak Chang
Dec 14, 2019·Plastic and Reconstructive Surgery·Mahnood S Choudhery
Sep 2, 2020·Archives of Craniofacial Surgery·Ki Yong Hong
Dec 13, 2019·Stem Cells International·Muhammad M BashirMahmood S Choudhery
Nov 26, 2019·Plastic and Reconstructive Surgery·Shengyang Jin, Facheng Li
Nov 26, 2019·Plastic and Reconstructive Surgery·Ki Yong HongHak Chang
Jan 28, 2020·Plastic and Reconstructive Surgery·Mahnood S Choudhery
Jan 28, 2020·Plastic and Reconstructive Surgery·Ki Yong HongHak Chang
Dec 29, 2020·Aesthetic Surgery Journal·Il-Kug KimHak Chang
Mar 16, 2021·Frontiers in Bioengineering and Biotechnology·Yuan YeJindou Jiang
Jun 10, 2021·Experimental Biology and Medicine·J Sarah CrowleyMarek Dobke
Nov 17, 2020·Annals of Plastic Surgery·Yaping QuSu Fu