Systemic administration of insulin-like growth factor I (IGF-I) causes growth of the rat prostate

The Journal of Urology
N TørringE Nexø

Abstract

To investigate the effects of insulin-like growth factor I (IGF-I) and epidermal growth factor (EGF) on the rat prostate. In addition, we investigated the effect of ornithine decarboxylase (ODC) inhibition with alpha-diflouromethylornitine (DFMO) on the expected growth of the prostate. Eight week old Wistar rats were allocated into groups of eight, receiving systemic treatment for 3 and 7 days with either IGF-I (400 micrograms/rat/day) or EGF (30 micrograms/rat/day) alone or in combination with DFMO. Systemic treatment with IGF-I for 7 days resulted in a 29% (p < 0.01) increase in the mean wet weight of the ventral prostate. The mean weight of the dorsolateral lobe of the prostate increased by 39% (p < 0.05), and the seminal vesicle and coagulating gland increased 69% (p < 0.05) compared to controls. The ODC-activity in the prostate was significantly increased by IGF-I after 3 days of treatment, and administration of IGF-I concomitantly with DFMO significantly inhibited ODC activity and the weight increase of the prostate. Stereological examination of the prostate in the IGF-I-treated animals showed growth of the epithelial component of the gland. Systemic treatment with EGF did not affect the mean weight of the prostate or the...Continue Reading

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Citations

Jul 12, 2002·The Prostate·Anand P ChokkalingamAnn W Hsing
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Dec 31, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carmelo Nieves, Bobbi Langkamp-Henken
Nov 27, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Bogdan MarekEwa Janczewska-Kazek
Jan 28, 2009·BMC Cancer·Curt E HarperCoral A Lamartiniere
Jun 26, 2007·Asian Journal of Andrology·Bernard RobaireSophie-Anne Lamour
Mar 25, 2006·Future Oncology·Maurice P Zeegers, Harry Ostrer
Aug 26, 2011·Differentiation; Research in Biological Diversity·Ian D McLarenWade Bushman
May 4, 2011·Differentiation; Research in Biological Diversity·Zongwei Wang, Aria F Olumi
Dec 21, 2006·BJU International·Miles A GoldstrawRoger S Kirby
Sep 3, 2016·International Journal of Molecular Sciences·Kin-Mang Lau, Ka-Fai To
Nov 13, 2002·European Journal of Clinical Nutrition·L S AugustinC La Vecchia
Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Domenico PreziosoKeith Griffiths
Jan 5, 2002·Scandinavian Journal of Urology and Nephrology·N TørringE Nexø

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