Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats

European Journal of Pharmacology
H BaranW Loscher

Abstract

The endogenous neuroinhibitory and neuroprotective excitatory amino acid receptor antagonist kynurenic acid has been hypothetically linked to the pathogenesis of epilepsy and several other brain disorders. In the present study, alterations in kynurenic acid levels were examined in the kainate model of temporal lobe epilepsy. Kainate was systemically injected in rats at a dose (10 mg/kg s.c.) which induces a characteristic behavioural syndrome with stereotypies and focal (limbic) and generalized seizures, eventually progressing into severe status epilepticus. Kynurenic acid was determined 3 h after kainate injection in various brain regions (olfactory bulb, frontal cortex, piriform cortex, amygdala, hippocampus, nucleus accumbens, caudate/putamen, thalamus, superior and inferior colliculus, pons and medulla, and cerebellar cortex) and in plasma, using a sensitive high-performance liquid chromatographic method. When data were analysed irrespective of individual seizure severity, significant increases in kynurenic acid were determined in all brain regions examined except the hippocampus, nucleus accumbens and pons/medulla. The most marked (200-500%) increases above controls were seen in the piriform cortex, amygdala, and cerebella...Continue Reading

References

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Citations

Dec 28, 2011·Journal of Neural Transmission·Tomasz ŻarnowskiMaciej Gasior
Jun 9, 2012·Nature Reviews. Neuroscience·Robert SchwarczHui-Qiu Wu
Mar 1, 1997·Pediatric Research·H BaranG Lubec
Jul 31, 2001·Pediatric Research·G Ceresoli-Borroni, R Schwarcz
Mar 12, 2011·Journal of Pharmaceutical and Biomedical Analysis·Dénes ZádoriAntal Péter
Feb 13, 2007·Biomedical Chromatography : BMC·Takeshi FukushimaToshimasa Toyo'oka
Apr 17, 2015·Current Neurology and Neuroscience Reports·Marylou V Solbrig, Guey-Chuen Perng
Jun 8, 2017·Journal of Separation Science·Ilona SadokMagdalena Maria Staniszewska
May 27, 2016·International Journal of Tryptophan Research : IJTR·Halina BaranBerthold Kepplinger
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·Halina BaranMarkus Draxler
Nov 19, 1997·Journal of Neuroscience Research·P GuidettiR Schwarcz
Aug 16, 2005·Journal of the Neurological Sciences·Zsuzsanna HartaiLaszlo Vecsei

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