Systemic administration of leptin decreases plasma corticosterone levels: role of hypothalamic norepinephrine

Brain Research
Kimberly A ClarkP S MohanKumar

Abstract

Leptin, an adipocyte-derived hormone, is known to regulate a variety of neuroendocrine functions. It inhibits the hypothalamo-pituitary-adrenal axis (HPA) in several animal models, however, the exact mechanism by which it does so is not known. Since norepinephrine (NE) is a key regulator of the HPA axis, we hypothesized that leptin could suppress HPA activity by decreasing NE levels. To study this, we implanted adult male Sprague-Dawley rats with both a push-pull cannula in the paraventricular nucleus (PVN) and a catheter in the jugular vein. Animals were treated with either 0 or 100 microg or 500 microg of recombinant rat leptin (Lep). Push-pull perfusion was performed from 1000-1600 h. Perfusate samples were collected every 30 min and analyzed for NE levels using HPLC-EC. Blood samples were collected every 60 min and analyzed for corticosterone (CS) levels. To further understand the role of NE in this phenomenon animals were treated with either an alpha1-adrenergic agonist, phenylephrine (PHE; 0.5 mg/kg BW), an alpha2-adrenergic agonist, clonidine (CLON; 0.6 mg/kg BW), or a beta-adrenergic agonist, isoproterenol (ISO; 0.2 mg/kg BW) alone or in combination with 500 microg of Lep. Pre-treatment and hourly post-treatment blood s...Continue Reading

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Citations

Mar 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C ShinP S MohanKumar
Mar 1, 2014·The Journal of Endocrinology·Saadia BasharatChristopher D John
Feb 2, 2012·General and Comparative Endocrinology·Eric W RoubosLu Xu
Feb 4, 2010·Trends in Endocrinology and Metabolism : TEM·Tatsushi OnakaGareth Leng
Feb 16, 2010·Optometry : Journal of the American Optometric Association·Joseph N Trachtman
Nov 8, 2018·The Journal of Endocrinology·Viktorija GustaityteWalter Raasch
Mar 20, 2019·Nutrition & Diabetes·Andrew C ShinPuliyur S MohanKumar
Sep 21, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Andrew C ShinPuliyur S MohanKumar
Jul 25, 2021·Brain, Behavior, and Immunity·Richard J SimpsonKarsten Krüger

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