PMID: 7542899Apr 1, 1995Paper

Systemic administration of rhIGF-I or rhIGF-I/IGFBP-3 increases cortical bone and lean body mass in ovariectomized rats

Bone
C M BagiA Sommer

Abstract

The purpose of this study was to compare dose-related effects on cortical bone and lean body mass following subcutaneous administration of rhIGF-I alone, or bound to an equimolar amount of rhIGFBP-3 to adult Ovx rats. At the age of 16 weeks, rats were ovariectomized or sham-operated and were allowed 8 weeks to develop osteopenia. After being divided into control (saline treated) or treatment groups, rats were injected daily during an 8-week period with 0.9 and 2.6 mg/kg of rhIGF-I, or with 0.9, 2.6, and 7.5 mg/kg of rhIGF-I bound to rhIGFBP-3. Fluorescent bone markers were given 9 and 2 days prior to necropsy. Body weights and lean body mass were monitored throughout the experiment. Cortical bone histomorphometry was performed on tibial cross-sections at the tibiofibular junction, and endochondral bone growth was measured at the distal femoral metaphysis. All rats treated with rhIGF-I or the rhIGF-I/IGFBP-3 complex had increased body weights, corresponding to a dose-dependent increase in lean body mass. Endochondral growth was slightly increased in all experimental groups, but was not dose-dependent. A dramatic increase in periosteal, modeling-dependent formation, coupled with decreased or unchanged resorption on the endocortic...Continue Reading

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Citations

May 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S KasugaiK Ohya
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Govinda BhattaraiHo-Keun Yi
Jul 5, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F BaussL Kling
Mar 1, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Andreas Hoeflich
Jun 27, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·W WangE Svanberg
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J SvenssonB A Bengtsson
Jun 2, 2009·Expert Opinion on Investigational Drugs·Gui Tong TranEleftherios Tsiridis
Jan 1, 1995·Progress in Growth Factor Research·S AdamsA Sommer
Jan 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·Charles H LangThomas C Vary
May 16, 2000·European Journal of Clinical Investigation·E SvanbergK Lundholm
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K NarusawaY Seino
Mar 12, 1998·Endocrine Reviews·C OhlssonM C Slootweg
Feb 2, 2002·Journal of Drug Targeting·S A Gittens, H Uludag
Apr 12, 2001·European Journal of Clinical Investigation·E SvanbergD Mascarenhas
Oct 26, 2002·The Journal of Veterinary Medical Science·Boonrit ThongsongKenichiro Ono

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