Systemic and behavioral effects of intranasal administration of silver nanoparticles

Neurotoxicology and Teratology
Laurie L DavenportMary Beth Genter

Abstract

Use of silver nanoparticles (AgNPs) for their antimicrobial properties is widespread. Much of the previous work on the toxicity of AgNPs has been conducted in vitro or following oral or intravenous administration in vivo. Intranasal (IN) instillation of AgNPs mimics inhalation exposure and allows further exploration of the toxicity of these particles via respiratory tract exposure. The present study involved 1) single-dose exposures to assess tissue distribution and toxicity and 2) repeated exposures to assess behavioral effects of IN AgNP exposure (nominally uncoated 25 nm AgNP). AgNP deposition was localized in the liver, gut-associated lymphoid tissue, and brain. Decrease cellularity in spleen follicles was observed in treated mice, along with changes in cell number and populations in the spleen. The splenic GSH:GSSG ratio was also reduced following AgNP exposure. Expression of the oxidative stress-responsive gene Hmox1 was elevated in the hippocampus, but not cortex of treated mice, as was the level of HMOX1 protein. Mice receiving 7 days of IN exposure to 50 mg/kg AgNPs exhibited similar learning- and memory-related behaviors to control mice, except that treated mice spent significantly less time in the target quadrant of ...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Aug 23, 2000·European Journal of Clinical Pharmacology·K FattingerD Verotta
Jan 11, 2000·The Proceedings of the Nutrition Society·W Dröge, R Breitkreutz
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 21, 2006·Pharmaceutical Research·Ulrika Espefält WestinErik Björk
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Nov 21, 2007·Toxicology Letters·X Chen, H J Schluesener
Mar 12, 2011·Environmental Science & Technology·Christine Ogilvie HendrenMark R Wiesner
May 10, 2011·Microbial Ecology·Arunava PradhanFernanda Cássio
Jul 27, 2011·Environmental Toxicology and Pharmacology·Eun-Jung ParkKwangsik Park
Nov 14, 2012·Ecotoxicology and Environmental Safety·Peidang LiuNing Gu
Apr 30, 2013·Small·Cindy GunawanRose Amal
Jul 3, 2013·Environmental Health Perspectives·Nate Seltenrich
Dec 7, 2013·SpringerPlus·Shigekazu KuriharaKenji Ak Tanaka

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Citations

Jun 15, 2016·Nanoscale Research Letters·Bin SongLongQuan Shao
Jul 19, 2016·Toxicology·Beata Dąbrowska-BoutaLidia Strużyńska
Jul 28, 2016·Neurotoxicology·Harm J HeusinkveldRoel P F Schins
Jun 9, 2016·Electrophoresis·Andrea Mathilde MebertMartín Federico Desimone
Jun 18, 2017·Nanotoxicology·Luisa CampagnoloAntonio Pietroiusti
Dec 5, 2015·International Journal of Toxicology·David L MillerMary Beth Genter
Oct 11, 2017·International Journal of Molecular Sciences·Elisa RodaTeresa Coccini
Nov 28, 2017·Journal of Biomolecular Structure & Dynamics·Sara RahmaniMojtaba Falahati
Jun 27, 2018·Journal of Applied Toxicology : JAT·Lucía Z Flores-LópezRatnasamy Somanathan
Mar 14, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Yingzhu Li, Enda Cummins
Oct 1, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ivana JarakIola F Duarte
Jun 8, 2017·Scientific Reports·Angela B JavurekCheryl S Rosenfeld
Jun 6, 2019·Beilstein Journal of Nanotechnology·Zaid K AlghrairBahram Ebrahimi
Feb 7, 2021·Toxics·Anna A AntsiferovaMikhail V Kovalchuk
Mar 27, 2021·Reviews on Environmental Health·Abbas Mohammadipour, Mahmoud Abudayyak
Jun 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengting ShangYuying Xue

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