Systemic and local delivery of mesenchymal stem cells for heart renovation: Challenges and innovations

European Journal of Pharmacology
Ziwei LiuXiaohui Zhou

Abstract

In the beginning stage of heart disease, the blockage of blood flow frequently occurs due to the persistent damage and even death of myocardium. Cicatricial tissue developed after the death of myocardium can affect heart function, which ultimately leads to heart failure. In recent years, several studies carried out about the use of stem cells such as embryonic, pluripotent, cardiac and bone marrow-derived stem cells as well as myoblasts to repair injured myocardium. Current studies focus more on finding appropriate measures to enhance cell homing and survival in order to increase paracrine function. Until now, there is no universal delivery route for mesenchymal stem cells (MSCs) for different diseases. In this review, we summarize the advantages and challenges of the systemic and local pathways of MSC delivery. In addition, we also describe some advanced measures of cell delivery to improve the efficiency of transplantation. The combination of cells and therapeutic substances could be the most reliable method, which allows donor cells to deliver sufficient amounts of paracrine factors and provide long-lasting effects. The cardiac support devices or tissue engineering techniques have the potential to facilitate the controlled r...Continue Reading

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Citations

Sep 17, 2020·Journal of Drug Targeting·Cuican LiZhou Xiaohui
Jun 24, 2020·Biochemistry. Biokhimii︠a︡·B V Chernyak
Aug 26, 2020·Pharmaceutical Research·Reyaj MikraniXiaohui Zhou
Feb 14, 2021·Journal of Hematology & Oncology·Tian ZhouPeilong Lai
May 7, 2021·Stem Cell Reviews and Reports·Santosh GuptaRama Shanker Verma

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