PMID: 6969562Nov 1, 1980Paper

Systemic and local lymphocyte responses in experimental hypersensitivity pneumonitis

The American Review of Respiratory Disease
H V RatajczakH B Richerson

Abstract

The pathogenesis of hypersensitivity pneumonitis is incompletely understood; cell-mediated hypersensitivity mechanisms may be involved, but in vitro correlates have been studied in humans with inconclusive results. We used a rabbit model of hypersensitivity pneumonitis to study systemic and local antigen-specific lymphocyte responses as measured by in vitro incorporation of 3H-thymidine. Groups of animals were systemically immunized with ovalbumin and acutely or repeatedly challenged with aerosolized ovalbumin. Lymphocyte responses were measured in peripheral blood, mediastinal and popliteal lymph nodes, bronchus-associated lymphoid tissue, and bronchoalveolar wash fluids in these groups and in appropriate control animals. Lymphocyte proliferative responses to specific antigen, shown previously to be a T-cell response in this system, occurred after systemic or inhalation exposure to antigen. Acute alveolitis was associated with a decrease in peripheral blood lymphocyte responses and the presence of responsive lymphocytes in bronchoalveolar was fluids. Repeated inhalation challenge thrice weekly for 1 month, with waning of alveolitis, was not associated with significant changes in lymphocyte responsiveness. Antigen-specific lymp...Continue Reading

Citations

Dec 1, 1991·The American Review of Respiratory Disease·J Defaveri, J R Graybill
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·D N WeissmanM R Schuyler
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J TodtJ L Curtis
Nov 1, 1991·American Journal of Respiratory Cell and Molecular Biology·H B RichersonD Lubaroff
Jul 1, 1990·The American Review of Respiratory Disease·J S BermanD M Center
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey L CurtisLloyd M Stoolman
May 19, 2005·Toxicological Reviews·Helen V Ratajczak
May 1, 1989·Toxicology and Industrial Health·R L SherwoodC Aranyi
Jul 1, 1991·Disease-a-month : DM·O P Sharma

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