PMID: 3770872Nov 1, 1986Paper

Systemic and renal vascular responses to dietary calcium and vitamin D

Hypertension
E T ZawadaD E McClung

Abstract

To assess the consequences of hypercalcemia on systemic and renal hemodynamics, vasoactive hormones, and water and electrolyte excretion in intact, conscious mongrel dogs, measurements in 10 dogs receiving 100 mg/kg calcium gluconate and 10,000 U/kg vitamin D daily for 2 weeks were compared with measurements made in 10 time-control dogs not receiving calcium or vitamin D. Hypercalcemia induced by dietary supplementation with calcium and vitamin D resulted in profoundly reduced glomerular filtration rate (40 vs 78 ml/min in controls; p less than 0.005), estimated renal plasma flow (145 vs 267 ml/min in controls; p less than 0.005), and renal blood flow (254 vs 441 ml/min in controls; p less than 0.005). Renal resistance was significantly increased in the hypercalcemic dogs (0.57 +/- 0.07 vs 0.28 +/- 0.01 mm Hg/ml/min; p less than 0.005). Hypercalcemia also resulted in increased fractional excretion of water (4.8 vs 1.4% in controls; p less than 0.005), sodium (1.4 vs 0.6% in controls; p less than 0.005), calcium (1.7 vs 0.7% in controls; p less than 0.01), and magnesium (10.2 vs 4.1% in controls; p less than 0.005). Systolic blood pressure (160 vs 172 mm Hg in controls; p less than 0.05) and stroke volume were lower (0.024 vs 0....Continue Reading

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Citations

Apr 1, 1993·Journal of Clinical Pharmacology·D A SaelensJ M Lembke
Mar 1, 1989·Clinical and Experimental Pharmacology & Physiology·T KitaK Tanaka
Aug 7, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jerrold PetrofskyRakhi Save
Nov 1, 1996·The Veterinary Clinics of North America. Small Animal Practice·J M KrugerK R Refsal
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·J J TreshamB A Scoggins
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·S N Baksi

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