PMID: 8938631Oct 1, 1996Paper

Systemic and splanchnic hemodynamic changes in patients with hepatic schistosomiasis

Liver
C DeniéD Lebrec

Abstract

Although hepatic schistosomiasis is a common cause of portal hypertension, only a few hemodynamic studies, in humans, have been published on this subject. The aim of this study was to determine the systemic and splanchnic hemodynamic changes in hepatic schistosomiasis and to evaluate the influence of liver fibrosis on these changes. A retrospective analysis of a series of 13 patients with hepatic schistosomiasis who had undergone hemodynamic studies was performed. Portal or perisinusoidal fibrosis was present at liver biopsy in 8 patients. The control group included 22 patients with chronic hepatitis and normal hepatic venous pressure gradients. Patients with schistosomiasis exhibited high cardiac index (4.11 +/- 1.15 l.min-1.m-2 vs 2.99 +/- 0.85 l.min-1.m-2; p < 0.05) and low systemic vascular resistance (1039 +/- 316 dyn.s.cm-5 vs 1334 +/- 336 dyn.s.cm-5; p < 0.05). The hepatic venous pressure gradient and hepatic blood flow were normal. Azygos blood flow was markedly increased (0.90 +/- 0.66 l.min-1 vs 0.13 +/- 0.04 l.min-1; p < 0.05). Hemodynamic values were not significantly different between patients with liver fibrosis and those without fibrosis at liver biopsy. In conclusion, patients with hepatic schistosomiasis had a ...Continue Reading

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Citations

Feb 27, 2007·Parasitology Research·Roba M TalaatMaged M Al-Sherbiny
Apr 9, 2010·Clinical Microbiology Reviews·Alicia HidronAnis Rassi
Feb 28, 2016·Digestive Diseases and Sciences·Bernardo Times de CarvalhoSimone Cristina Soares Brandão
Apr 20, 2007·Clinical Cardiology·Carlos Franco-ParedesJ W Hurst
Aug 13, 2015·PloS One·Luiz Arthur Calheiros LeiteVera Lucia de Menezes Lima
Jul 27, 2001·Current Gastroenterology Reports·T W Schafer, B R Hale
Mar 26, 2021·PLoS Neglected Tropical Diseases·Francesca TamarozziFederico G Gobbi
Apr 26, 2005·Journal of the American College of Surgeons·Adeyemi O LaosebikanNamasha M Naidoo

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