PMID: 8584236Oct 20, 1995Paper

Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model

Neuroscience Letters
Y W LeeT L Yaksh

Abstract

The effects of intraperitoneal (I.P.), intracerebroventricular (ICV) and intrathecal (IT) opiates were studied in the rat neuropathic pain model of Kim and Chung. Dose dependent reduction of allodynia was observed after I.P. and ICV morphine, but not after IT morphine, IT or ICV c[D-pen2 D-pen5]enkephalin (DPDPE) (delta agonist), or IT or ICV U50488H (kappa agonist). The effects of ICV morphine were blocked by I.P. naloxone, but not by IT methysergide, phentolamine or 8-sulfophenyltheophylline. Catalepsy (immobility) was observed after IT, ICV and IT morphine but this was not reliably associated with a reduction of allodynia. I.P. and ICV morphine may thus reduce tactile allodynia via supraspinal, but not spinal, mu opioid receptors.

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Citations

Mar 17, 2001·Current Pain and Headache Reports·M S Wallace
Dec 29, 2004·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·G L Y Cheing, M L M Luk
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Linda S Sorkin, Tony L Yaksh
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