PMID: 3766770Oct 1, 1986Paper

Systemic angiotensin acts at subfornical organ to facilitate activity of neurohypophysial neurons

The American Journal of Physiology
A V Ferguson, L P Renaud

Abstract

Extracellular single unit recordings were obtained to investigate the effects of systemic administration of angiotensin II (ANG II) on the excitability of antidromically identified neurohypophysial neurons in the rat. Records were obtained from 89 oxytocin- or vasopressin-secreting neurons in the hypothalamic supraoptic or paraventricular nuclei. Increased excitability in response to ANG II was observed in 83% of putative vasopressin- and 75% of putative oxytocin-secreting neurons tested in intact animals. Lesion studies to identify the central nervous system site of action for such peripherally administered ANG II showed that, after electrolytic lesion of the rostral subfornical organ (SFO), neurohypophysial neurons demonstrated no increase in excitability in response to this peptide. In an attempt to correlate the synaptic events through which activation of SFO neurons may result in facilitated excitability of neurohypophysial cells, 19 cells were tested with both systemic ANG II and electrical stimulation in the SFO. These studies demonstrated that all cells which showed long-duration increases in excitability in response to electrical stimulation of SFO were also activated by systemic ANG II. It is concluded that the SFO is...Continue Reading

Citations

Dec 21, 2002·Acta Physiologica Scandinavica·G M ToneyS D Stocker
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph D WalchJ Thomas Cunningham
Jan 10, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jose V MenaniAlan Kim Johnson
Jun 19, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Annette D de KloetColin Sumners
Jan 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen L BarnesMichael C Andresen
May 14, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pauline M Smith, Alastair V Ferguson
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M SchreihoferA F Sved
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Nov 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kaushik P PatelHong Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.