Systemic antibiotics and tooth loss in periodontal disease.

Journal of Dental Research
J Cunha-CruzB Saver

Abstract

Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.

References

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Jan 30, 2007·Journal of Clinical Periodontology·Barry G SaverGerardo Maupomé

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Citations

Mar 30, 2010·Journal of Dental Research·L M GolubJ B Payne
Apr 12, 2011·BMC Public Health·Takashi HaniokaHideo Tanaka
Dec 8, 2010·Periodontology 2000·Andrea MombelliAdnan Almaghlouth
Dec 24, 2015·PloS One·Caroline Moura Martins Lobo SantosBranca Heloisa Oliveira
Apr 27, 2019·Journal of Clinical Periodontology·Omar HelalFalk Schwendicke
May 18, 2021·Journal of Clinical Periodontology·Rui CarvalhoLeandro Chambrone

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