Abstract
Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.
References
Feb 1, 1992·Journal of Clinical Periodontology·W J LoescheB A Smith
Jan 21, 1989·British Dental Journal·M A LewisE Kay
Feb 1, 1993·Journal of Periodontology·T IngmanL M Golub
Aug 1, 1995·Journal of Clinical Periodontology·A D HaffajeeS S Socransky
May 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·W J LoescheM A Schork
Jul 3, 1998·Journal of Clinical Periodontology·T BerglundhJ Lindhe
Apr 1, 1999·Journal of Clinical Periodontology·R M PalmerR F Wilson
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·W J Loesche
Jun 28, 2000·British Dental Journal·N A PalmerM V Martin
Jan 3, 2001·The New England Journal of Medicine·C G WhitneyUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
May 1, 2001·Journal of Periodontology·B SiguschE Glockmann
Apr 6, 2002·The Journal of the American Dental Association·Walter J LoescheNiko Kaciroti
Apr 23, 2002·Journal of Clinical Periodontology·J RooneyM Addy
Jun 6, 2003·Journal of Clinical Periodontology·David HerreraSilvia Roldán
Feb 20, 2004·Annals of Periodontology·Anne D HaffajeeJohn C Gunsolley
May 15, 2004·Journal of Clinical Periodontology·Rosa Maria J RodriguesAna Paula V Colombo
May 26, 2004·Immunology Letters·Helena Tlaskalová-HogenováAlena Kokesová
Oct 19, 2004·Odontology·Jan Bergström
Mar 16, 2005·Journal of Clinical Periodontology·A MombelliC Giannopoulou
May 19, 2005·Journal of Periodontology·Benjamin EhmkeThomas F Flemmig
Dec 3, 2005·The New England Journal of Medicine·Vivian G LooAndré Dascal
Jun 1, 2006·Journal of Periodontology·J Cunha-CruzP P Hujoel
Jan 30, 2007·Journal of Clinical Periodontology·Barry G SaverGerardo Maupomé
Citations
Mar 30, 2010·Journal of Dental Research·L M GolubJ B Payne
Apr 12, 2011·BMC Public Health·Takashi HaniokaHideo Tanaka
Oct 25, 2014·British Dental Journal·C M FaggionJ Wasiak
Dec 15, 2015·Journal of Periodontology·Andrea MombelliCatherine Giannopoulou
Dec 8, 2010·Periodontology 2000·Andrea MombelliAdnan Almaghlouth
Jan 10, 2013·Journal of Clinical Periodontology·Mayra Xavier E Silva-SenemAna Paula Vieira Colombo
Dec 24, 2015·PloS One·Caroline Moura Martins Lobo SantosBranca Heloisa Oliveira
Jul 10, 2012·Operative Dentistry·S R KwonG Denehy
Apr 27, 2019·Journal of Clinical Periodontology·Omar HelalFalk Schwendicke
May 18, 2021·Journal of Clinical Periodontology·Rui CarvalhoLeandro Chambrone