Systemic antibiotics for treating diabetic foot infections

The Cochrane Database of Systematic Reviews
Anna Selva OlidBenjamin A Lipsky

Abstract

Foot infection is the most common cause of non-traumatic amputation in people with diabetes. Most diabetic foot infections (DFIs) require systemic antibiotic therapy and the initial choice is usually empirical. Although there are many antibiotics available, uncertainty exists about which is the best for treating DFIs. To determine the effects and safety of systemic antibiotics in the treatment of DFIs compared with other systemic antibiotics, topical foot care or placebo. In April 2015 we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library); Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE, and EBSCO CINAHL. We also searched in the Database of Abstracts of Reviews of Effects (DARE; The Cochrane Library), the Health Technology Assessment database (HTA; The Cochrane Library), the National Health Service Economic Evaluation Database (NHS-EED; The Cochrane Library), unpublished literature in OpenSIGLE and ProQuest Dissertations and on-going trials registers. Randomised controlled trials (RCTs) evaluating the effects of systemic antibiotics (oral or parenteral) in people with a DFI. Primary outcomes were clinical ...Continue Reading

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Citations

Oct 10, 2015·Diabetes/metabolism Research and Reviews·Benjamin A Lipsky
Jun 15, 2017·The Cochrane Database of Systematic Reviews·Jo C DumvilleJun Xia
Aug 3, 2018·Current Infectious Disease Reports·Maria NikoloudiNikolaos Tentolouris
May 1, 2019·The International Journal of Lower Extremity Wounds·José Miguel NevesJosé Neves
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Mar 17, 2020·Diabetes/metabolism Research and Reviews·Benjamin A LipskyUNKNOWN International Working Group on the Diabetic Foot (IWGDF)
Mar 21, 2020·International Wound Journal·Pinar Sen, Tuna Demirdal
Aug 21, 2020·International Wound Journal·Tomás Pessoa E CostaJosé Neves
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Apr 16, 2021·The International Journal of Lower Extremity Wounds·Nese SaltogluUNKNOWN KLİMİK Society, Diabetic Foot Study Group
Oct 9, 2021·Frontiers in Medicine·Wei ChaiXuezhi Li

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