Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge

Virology
F BarrionuevoM Pérez-Filgueira

Abstract

The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. These results demonstrate that presence of antigen-specific antibodies is critical to prevent the dissemination of the virus within the animal. Conventional FMD vaccination additionally promoted the deployment of rapid, high titer and isotype-switched antibody responses at systemic and mucosal levels after infection, thus conferring protection even in the presence of low pre-challenge antibody titers.

References

Jun 8, 2002·Journal of the American Veterinary Medical Association·Johnny D CallahanWilliam M Nelson
Oct 9, 2002·Comparative Immunology, Microbiology and Infectious Diseases·Esteban DomingoFrancisco Sobrino
Jan 14, 2003·Revue Scientifique Et Technique·D ThompsonC Brown
Jan 16, 2003·Virus Research·Fred Brown
Jan 16, 2003·Virus Research·T R Doel
Jan 16, 2003·Virus Research·Paul SutmollerKeith J Sumption
Jul 16, 2003·Journal of Comparative Pathology·S AlexandersenA J M Garland
Sep 12, 2007·Veterinary Pathology·M Y GulbaharY B Kabak
Oct 22, 2008·The Veterinary Journal·Juan M PachecoLuis L Rodriguez
Mar 4, 2011·Transboundary and Emerging Diseases·J ArztL L Rodriguez
Oct 5, 2012·The Journal of General Virology·B Veronica CarrBryan Charleston
Jul 2, 2014·The Veterinary Clinics of North America. Food Animal Practice·Christie Balcomb, Derek Foster
May 23, 2015·Transboundary and Emerging Diseases·B P BritoA M Perez
May 12, 2016·Transboundary and Emerging Diseases·T J D Knight-JonesJ Rushton
Jun 21, 2016·Transboundary and Emerging Diseases·L RobinsonW Vosloo

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