Systemic antimicrobials adjuvant to periodontal therapy in diabetic subjects: a meta-analysis

Journal of Clinical Periodontology
Alessandra Pascotini GrellmannFabricio Batistin Zanatta

Abstract

Adjuvant antibiotics have been suggested to improve periodontal therapy in diabetic subjects. The aim of this study was to systematically review randomized clinical trials assessing systemic antimicrobial use adjuvant to scaling and root planing (SRP) versus SRP alone in diabetic subjects. The PubMed, Cochrane Central Register of Controlled Trials, EMBASE, TRIP, Web of Science and LILACS databases and the grey literature were searched through May 2015. Of 2534 potentially eligible studies, 13 were included in the systematic review. Weighted mean differences (WMDs) in probing depth (PD) reduction and clinical attachment level (CAL) gain (primary outcomes), and plaque index (PI) and bleeding on probing (BOP) reductions, were estimated using a random effect model. The WMD in PD reduction [-0.15 mm, n = 11, p = 0.001, 95% confidence interval (CI) -0.24, -0.06] favoured antibiotic use. WMDs in CAL gain, PI and BOP reductions (-0.14 mm, n = 9, p = 0.11, 95% CI -0.32, 0.03; 4.01%, n = 7, p = 0.05, 95% CI -0.04, 8.07; and -1.91%, n = 7, p = 0.39, 95% CI -6.32, 2.51 respectively) did not favour adjunctive antibiotic use. Adjunctive therapy may improve the efficacy of SRP in reducing PD in diabetic subjects.

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Citations

Oct 31, 2018·Clinical Oral Investigations·B PretzlY Jockel-Schneider
Mar 23, 2019·International Journal of Molecular Sciences·Daniela LiccardoGiuseppe Rengo
Aug 4, 2019·Journal of Periodontology·Holger F R JentschSigrun Eick
Aug 24, 2018·Journal of Clinical Periodontology·Jean-Noel VergnesUNKNOWN DIAPERIO Group
Dec 12, 2018·Journal of Clinical Periodontology·Yung-Ting HsuChun-Teh Lee

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