Systemic arterial hypertension in children following renal transplantation: prevalence and risk factors

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Manish D SinhaBritish Association for Paediatric Nephrology

Abstract

Control of blood pressure (BP) following renal transplantation may improve allograft and patient survival. Our aims were (i) to describe the distribution of BP and the prevalence of systolic and/or diastolic hypertension in children over the first 5 years following renal transplantation and (ii) to evaluate clinical risk factors and centre-specific factors associated with hypertension in this population. We conducted a retrospective case note review of all current paediatric kidney transplant patients in the UK, with data collected at 6 months, 1, 2 and 5 years following transplantation in subjects with hypertension (systolic and/or diastolic BP > 95th > ) and non-hypertensive subjects BP ≤ 95th > . In total, 27.3% (117/428), 27.6% (118/428), 26.0% (95/365) and 25.6% (50/195) of the patients were hypertensive (systolic and/or diastolic BP > 95th > ) at 6 months, 1, 2 and 5 years following transplantation, respectively. A total of 58.4% of the patients at 6 months, 52.8% at 1 year, 48.2% at 2 years and 48.2% at 5 years were receiving anti-hypertensive therapy, of whom 31.6-36.6% remained hypertensive. When subjects were identified as being hypertensive, on anti-hypertensive medication or had untreated hypertension (systolic and/...Continue Reading

References

Jul 1, 1995·Archives of Disease in Childhood·J V FreemanM A Preece
Oct 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H J BaluarteA Tejani
Feb 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N LingensK Schärer
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·J M SorofR J Portman
Feb 9, 2000·JAMA : the Journal of the American Medical Association·K C MangeH I Feldman
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M SorofR Portman
Jun 26, 2001·Pediatric Transplantation·M M MitsnefesP T McEnery
Oct 31, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H MorganJ W Balfe
Aug 13, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mark M MitsnefesPaul T McEnery
Aug 14, 2003·The Journal of Pediatrics·Mark M MitsnefesPaul T McEnery
Jun 25, 2004·The New England Journal of Medicine·Stephen P McDonaldUNKNOWN Australian and New Zealand Paediatric Nephrology Association
Jul 15, 2004·Transplantation Proceedings·T SeemanJ Janda
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Aug 19, 2004·Transplantation·Jaap W GroothoffUNKNOWN Dutch cohort study
Nov 30, 2004·Statistics in Medicine·David J Spiegelhalter
Jan 18, 2005·World Journal of Surgery·Kiyokazu AkiokaShinichi Ohshima
Sep 24, 2005·Pediatric Transplantation·Erkin SerdarogluAfig Berdeli
May 9, 2006·Pediatric Transplantation·Tomás SeemanJan Janda
Oct 24, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomás Seeman
Nov 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte Hadtstein, Franz Schaefer
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Jul 25, 2009·Journal of Hypertension·Empar LurbeUNKNOWN European Society of Hypertension
Oct 23, 2009·The New England Journal of Medicine·Elke WühlFranz Schaefer
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Manish D SinhaJohn M Simpson
Dec 31, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Karlijn J van StralenFrancesco Emma

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Citations

Sep 27, 2012·Current Hypertension Reports·Tomáš Seeman
Dec 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giulia GhirardoLuisa Murer
Jan 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bora GülhanNesrin Beşbaş
Dec 15, 2015·American Journal of Hypertension·Stella StabouliFotios Papachristou
Aug 16, 2015·Advances in Medical Sciences·Maria Roszkowska-Blaim, Piotr Skrzypczyk
Nov 30, 2014·Current Hypertension Reports·Susan Halbach, Joseph Flynn
Oct 21, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David K Hooper, Mark Mitsnefes
Dec 6, 2018·Current Opinion in Organ Transplantation·Beau KellyGeorge V Mazariegos
Feb 6, 2015·Journal of the American Society of Nephrology : JASN·Matthew R WeirSandra J Taler
Dec 8, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rizky I SugiantoAnette Melk
Sep 5, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Britta HöckerBurkhard Tönshoff
Jun 11, 2020·Pediatrics·Michael E SeifertUNKNOWN IMPROVING RENAL OUTCOMES COLLABORATIVE (IROC)

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