Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats

Scientific Reports
Lucas Giglio ColliMaria Helena Catelli de Carvalho

Abstract

Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erectile dysfunction. However, the link between arterial hypertension and male reproductive disorders is associative at best. Moreover, many studies have reported associations between decreased male fertility and/or semen quality and alterations to general male health. In this study we aim to investigate the effect of systemic high blood pressure in sperm quality, sperm functional characteristics and testicular physiology in a rat model. Hypertensive rats presented altered testicular morphology - mainly vascular alterations and impaired testicular vasomotion. Hypertensive rats also presented decrease in sperm concentration, DNA integrity and increased percentages of sperm with dysfunctional mitochondria, intracellular superoxide anion activity and abnormal morphology. This study provides mechanistic insights by which arterial hypertension affects the testes, evidencing the testes as another target organ for hypertension as well as its im...Continue Reading

References

May 1, 1967·Acta Endocrinologica·J LevinE H Friedrich
Jun 1, 1982·Acta Physiologica Scandinavica·J E DamberT Tenland
Oct 1, 1981·American Journal of Clinical Pathology·T L AndresD J Lapenas
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Jan 1, 1995·Journal of Reproduction and Fertility·J F GriveauD Le Lannou
Oct 1, 1996·International Journal of Andrology·D JezekA Hittmair
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·N SaitoH Enzan
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·N ItohY Ohta
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·K AkagashiY Ohta
Oct 9, 1998·Cardiovascular Research·Y M PintoD Ganten
Sep 16, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·N Saito, H Kawamura
Sep 29, 2000·BMJ : British Medical Journal·R JacobsenH Moller
Mar 23, 2001·Upsala Journal of Medical Sciences·L O KoskinenA Bergh
May 15, 2003·Scandinavian Journal of Urology and Nephrology·Serdar TarhanCihan Göktan
Jun 19, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D P ToledoZ B Fortes
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Jun 1, 1964·The Journal of Physiology·B P SETCHELL, G M WAITES
Mar 25, 2004·Reproductive Biology and Endocrinology : RB&E·Dorota Sanocka, Maciej Kurpisz
Sep 20, 2005·Critical Care : the Official Journal of the Critical Care Forum·Christopher G EllisMichael Sharpe
Dec 24, 2005·Asian Journal of Andrology·J ErenpreissA Giwercman
Feb 28, 2006·Fertility and Sterility·Ricardo Pimenta BertollaMiguel Srougi
Jul 21, 2006·Asian Journal of Andrology·Saied Karbalay-DoustHossien Mirkhani
Oct 25, 2006·Hypertension·François FeihlBernard I Levy
Nov 25, 2006·Theriogenology·Gaffari TürkAli Osman Ceribaşi
Dec 13, 2006·Life Sciences·Graziela S CeravoloMaria Helena C Carvalho
Aug 19, 2007·Reproductive Biomedicine Online·B OzmenS Al-Hasani
Dec 25, 2007·Fertility and Sterility·Camile Garcia BlumerAgnaldo Pereira Cedenho
May 8, 2008·Journal of Cardiovascular Pharmacology·Stephen Fernandes RodriguesZuleica B Fortes
May 16, 2009·Current Hypertension Reports·François FeihlBernard Waeber
Jul 29, 2009·American Journal of Epidemiology·Tina Kold JensenErik Bostofte
Feb 19, 2010·Cardiovascular Research·Sergio Rey, Gregg L Semenza
Apr 10, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A RochaJ G Mill
May 20, 2011·BJU International·Camile Garcia BlumerAgnaldo Pereira Cedenho

❮ Previous
Next ❯

Citations

Jul 15, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Allan Peter DavisCarolyn J Mattingly
Dec 16, 2020·Scientific Reports·Ricardo P Bertolla
Jul 12, 2020·Journal of Reproductive Immunology·Gerhild Zauner, Guillermina Girardi
Mar 27, 2021·Frontiers in Physiology·Sina StuckerAnjali P Kusumbe
Jul 3, 2021·Microorganisms·Rafael K CamposShannan L Rossi
Aug 16, 2021·Reproductive Biomedicine Online·Irene HervásJosé María Martínez-Jabaloyas
Nov 28, 2021·Nature Reviews. Urology·R Clayton Edenfield, Charles A Easley

❮ Previous
Next ❯

Methods Mentioned

BETA
Protein Assay
electrophoresis

Software Mentioned

ImageJ Launcher
Axio Vision
IVOS
Computer Assisted Sperm Analysis system ( CASA System
Graph Pad Prism
Leica IM50 manager

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Cardiovascular Journal of South Africa : Official Journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners
© 2021 Meta ULC. All rights reserved