Systemic arteriovenous fistula leads to pulmonary artery remodeling and abnormal vasoreactivity in the fetal lamb

American Journal of Physiology. Lung Cellular and Molecular Physiology
Jean-Marie JouannicA Tuan Dinh-Xuan

Abstract

Several cases of systemic arteriovenous fistula diagnosed in the human fetus have been associated with the postnatal development of persistent pulmonary hypertension. The aim of this study was to determine the effects of a prenatally created systemic arteriovenous fistula on the structure and reactivity of the pulmonary circulation in the fetal lamb. A fistula between the jugular vein and carotid artery was created in fetal lambs at 119-124 days of gestation. At delivery (134-139 days), left pulmonary artery (LPA) pressure was increased in the fistula group (n = 12) compared with controls (n = 11, P < 0.01). The pulmonary vascular resistance was significantly higher in the fistula group (P < 0.05), whereas mean LPA blood flow was not statistically different between the two groups. Morphometric analysis of the pulmonary vascular bed revealed an increase in the number of peripheral muscular arteries, together with an increase in pulmonary arterial medial thickness in the fistula group. There was no difference in the relative number or size of intraacinar arteries. In vitro organ bath studies on pulmonary arterial rings showed impaired endothelium-dependent relaxation in the fistula group compared with controls. However, endotheli...Continue Reading

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Citations

Oct 9, 2007·Gynécologie, obstétrique & fertilité·L FriédérichE Verspyck
Apr 3, 2009·Prenatal Diagnosis·Elena SinkovskayaAlfred Abuhamad
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Tara KaramlouKent L Thornburg
Nov 24, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alexandra BenachiJacques R Bourbon
Mar 14, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Julien HoganAntoine Legendre

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