PMID: 3756830Nov 1, 1986Paper

Systemic aspergillosis as cause of myocardial infarction

Cancer
B S AnderssonK B McCredie

Abstract

Systemic aspergillosis is encountered with increasing prevalence in immunocompromised patients undergoing chemotherapy. The current communication describes the clinical and postmortem findings in three leukemic patients who developed myocardial infarction secondary to Aspergillus embolization of the coronary arteries. They were all immunosuppressed owing to previous chemotherapy and had been treated for suspected fungal infection with amphotericin B (0.6 mg/kg) for at least 1 week prior to this episode. It is postulated that the infection was spread through the blood since in all three cases the descending branch of the left coronary artery was occluded. Heart involvement resulting from fungal infection should be suspected when chest symptoms of unknown origin occur in this patient population.

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Citations

Oct 1, 1996·Clinical Cardiology·M B CishekS Schaefer
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J N CoxN Pochon
Jan 1, 1991·Cancer Investigation·F Meunier
Sep 1, 1993·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·L BerarducciS Devries
Jan 19, 1999·The Journal of Infection·Y RoubyM Huerre
Aug 1, 1990·American Heart Journal·J G RogersA R Easley
Sep 27, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Cynthia RackleyAndrew L Gilman

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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