Systemic Bone Loss After Fracture

Clinical Reviews in Bone and Mineral Metabolism
Benjamin OsipovBlaine A Christiansen

Abstract

A history of prior fracture is the most reliable indicator of prospective fracture risk. Increased fracture risk is not confined to the region of the prior fracture, but is operant at all skeletal sites, providing strong evidence of systemic bone loss after fracture. Animal and human studies suggest that systemic bone loss begins shortly after fracture and persists for several years in humans. In fact, bone quantity and bone quality may never fully return to their pre-fracture levels, especially in older subjects, demonstrating a need for improved understanding of the mechanisms leading to systemic bone loss after fracture in order to reduce subsequent fracture risk. Although the process remains incompletely understood, mechanical unloading (disuse), systemic inflammation, and hormones that control calcium homeostasis may all contribute to systemic bone loss. Additionally, individual factors can potentially affect the magnitude and time course of systemic bone loss and recovery. The magnitude of systemic bone loss correlates positively with injury severity and age. Men may also experience greater bone loss or less recovery than women after fracture. This review details the current understanding of systemic bone loss following f...Continue Reading

References

Sep 1, 1978·Annals of Human Biology·R H LargoP J Huber
Mar 1, 1976·Annals of Human Biology·J M TannerL F Resele
Apr 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M MuellerR Ziegler
Apr 1, 1991·British Journal of Rheumatology·N F PeelR G Russell
Feb 1, 1991·Seminars in Arthritis and Rheumatism·I Joffe, S Epstein
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R PacificiL V Avioli
Aug 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A D LeblancJ M Krebs
Feb 1, 1986·Acta Orthopaedica Scandinavica·M Härmä, P Karjalainen
Jul 1, 1974·Clinical Orthopaedics and Related Research·N E Westlin
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F Bonnarens, T A Einhorn
Jan 1, 1984·International Orthopaedics·O Johnell, B E Nilsson
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M Parfitt
Feb 27, 1995·The American Journal of Medicine·A J Silman
Jun 1, 1995·The Journal of Clinical Investigation·T BellidoS C Manolagas
Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P KannusI Vuori
Jan 1, 1994·American Journal of Physical Anthropology·C B RuffE Trinkaus
Aug 1, 1993·Acta Orthopaedica Scandinavica·M K KarlssonK J Obrant
May 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J B LauritzenI Transbøl
Aug 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T A EinhornM C Horowitz
Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K AkessonK J Obrant
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Pacifici
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·P SaftigK von Figura
Nov 20, 1998·Archives of Surgery·J SchröderF Stüber
Dec 11, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B M IngleR Eastell
Jan 11, 2000·Clinical Orthopaedics and Related Research·G HolzerT A Einhorn
Apr 25, 2000·Annual Review of Medicine·W B Ershler, E T Keller
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M KlotzbuecherM Berger
Feb 15, 2001·JAMA : the Journal of the American Medical Association·R LindsayE Seeman
Apr 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O JohnellJ A Kanis
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T KonT A Einhorn
Aug 31, 2001·Journal of the American Geriatrics Society·J A Yu-YahiroJ Magaziner
Dec 18, 2001·American Journal of Physical Anthropology·D E LiebermanO M Pearson
Feb 5, 2002·Archives of Internal Medicine·Fiona WuIan R Reid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gerontological Nursing
A D Houldin, B Hogan-Quigley
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Armaun J EmamiBlaine A Christiansen
American Journal of Physiology. Heart and Circulatory Physiology
Hai-Chao Han
Journal of the American Geriatrics Society
Jean-Philippe EmpanaEPIDOS Group
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
M L. Ogletree-HughesC S. Moravec
© 2021 Meta ULC. All rights reserved