Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Nicolas PelischMasakazu Kohno

Abstract

The renin-angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous system. We examined the effects of the angiotensin receptor blocker candesartan (10 mg kg(-1) per day, p.o.) on brain angiotensin II levels in angiotensin II-infused hypertensive rats. Angiotensin II or vehicle was infused subcutaneously for 14 days in Sprague-Dawley rats. Angiotensin II infusion resulted in increased blood pressure, an effect that was blocked by candesartan treatment. There was no effect of the angiotensin II infusion on Angiotensin II levels in the brain or on blood-brain barrier permeability. Brain tissue angiotensinogen and angiotensin converting enzyme mRNA levels were not changed by angiotensin II infusion but were decreased by candesartan treatment. At 2 weeks of treatment, CV11974, an active form of candesartan, was detectable in the plasma but was not detectable in brain tissue. These data suggest that treatment with candesartan decreases brain angiotensin II by decreasing brain angiotensinogen and angiotensin converting enzyme gene expression.

References

Dec 1, 1980·Neuroendocrinology·M L Mangiapane, J B Simpson
Oct 31, 1994·Brain Research·L P ReaganS J Fluharty
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Feb 23, 1996·Journal of Chromatography. B, Biomedical Applications·T MiyabayashiT Yashiki
Jul 3, 1998·European Journal of Pharmacology·W HäuserJ M Saavedra
Jan 19, 2002·Hypertension·Akira NishiyamaL Gabriel Navar
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·M J McKinleyS Y Chai
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mikhiela SherrodCurt D Sigmund
Jan 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LiThomas Unger
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jin ZhouJuan M Saavedra
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julia SmithShant Kumar
Aug 3, 2005·Cellular and Molecular Neurobiology·Juan M Saavedra
Aug 17, 2005·Current Protein & Peptide Science·O von Bohlen und Halbach
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Apr 4, 2007·The Journal of Clinical Investigation·Koji SakaiCurt D Sigmund
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Noriko IdeKoichi Node
Jan 8, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Melissa A Fleegal-DeMottaWilliam A Banks
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Claudia A McCarthyRobert E Widdop

❮ Previous
Next ❯

Citations

Jan 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gang LiuAkira Nishiyama
Nov 11, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Denovan P BeggRichard S Weisinger
May 11, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya KishiKenji Sunagawa
Mar 12, 2013·International Journal of Hypertension·Takuya Kishi, Yoshitaka Hirooka
Oct 11, 2012·Current Cardiovascular Risk Reports·Vera Novak
Feb 4, 2016·Current Hypertension Reports·Brent ShellJ Thomas Cunningham
Jun 26, 2012·Geriatrics & Gerontology International·Masaki Mogi, Masatsugu Horiuchi
Dec 17, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaki Mogi, Masatsugu Horiuchi
Feb 4, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshitaka HirookaKenji Sunagawa
Apr 29, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka HirookaKenji Sunagawa
Jul 7, 2018·Pflügers Archiv : European journal of physiology·Franziska SchusterWalter Raasch
Jan 22, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Rafael Rivas-SantistebanRafael Franco
Apr 10, 2021·Metabolic Brain Disease·Golnoush MirzahosseiniTauheed Ishrat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Masaki Mogi, Masatsugu Horiuchi
Hypertension Research : Official Journal of the Japanese Society of Hypertension
Emi Omura-MatsuokaKazuo Kitagawa
The British Journal of Psychiatry : the Journal of Mental Science
R EmsleyD Chalton
The British Journal of Psychiatry : the Journal of Mental Science
A J Bremner, A Regan
© 2022 Meta ULC. All rights reserved