PMID: 375095Dec 29, 1978Paper

Systemic candidiasis in mice treated with prednisolone and amphotericin B. 1. Morbidity, mortality and inflammatory reaction

Mycopathologia
W Blyth, G E Stewart

Abstract

Prednisolone potentiated candidiasis in mice when given as dosages of 1 mg, s.c. at-1 and + 24 h in relation to the time of inoculation, i.p. with any of 4 isolates of C. albicans which differed in degree of pathogenicity. Enhancement was shown by increased intra-abdominal colonisation, haematogenous dissemination and percentage mortality. There was at least a seven-fold increase in the mean area occupied by fungal colonies in median, longitudinal sections of kidneys after prednisolone treatment. Compared with those of fungal controls, renal lesions were deficient in inflammatory cells, only a few polymorphonuclear leukocytes occurring peripherally. Amphotericin B (AmB) at a non-toxic, total dosage of 0.5 mg given in two injections of 0.25 mg, i.p. at intervals of 24 h rendered infections non-lethal, or significantly reduced their severity, when started 24 or 48 h after inoculation. When antifungal treatment was delayed until 72 h, however, early deaths occurred despite the fact that the mean renal section area occupied by pseudomycelium was little more than that of controls and fibrosis of lesions was characteristic. Early mortalities increased even further when AmB, commencing at 72 h, was combined with prednisolone. This eff...Continue Reading

References

Mar 1, 1975·Journal of General Microbiology·E F GaleT Y Koh
Jan 1, 1967·Advances in Immunology·A E Gabrielsen, R A Good
Jun 1, 1969·Sabouraudia·P J KozinnA Teitler
Mar 1, 1970·The Journal of Experimental Medicine·J Thompson, R van Furth
Aug 1, 1966·The Journal of Experimental Medicine·P A Ward
Aug 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·E SELIGMANN
Jan 1, 1961·Sabouraudia·H F HASENCLEVER, W O MITCHELL
Sep 1, 1960·The Journal of Clinical Investigation·D B LOURIAH G BROWNE

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.