Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons

Neuroscience
H KashibaE Senba

Abstract

While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level. Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprotachykinin, gamma-preprotachykinin, somatostatin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, galanin, neuropeptide Y and neurotrophin receptor family (trkA, trkB, trkC) genes in dorsal root ganglion neurons by in situ hybridization in adult rats. Nerve growth factor is thought to be involved in the regulation of some of these genes. In the control animals, beta-preprotachykinin, gamma-preprotachykinin, calcitonin gene-related peptide, somatostatin, trkA, trkB and trkC messenger RNAs were found in about 30%, 30%, 40%, 10%, 40%, 5% and 20% of the lumbar dorsal root ganglion neurons, respectively. The number of neurons expressing beta/gamma-preprotachykinin and calcitonin gene-related peptide messenger RNAs decreased to about 50% and 70% of the control values, respectively, six days after subcutaneous administration of capsaicin (950 mg/kg). Simultaneously, the number of trkA messenger RNA-expr...Continue Reading

References

Aug 18, 1978·Brain Research·T M JessellA C Cuello
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S O MeakinE M Shooter
Sep 1, 1992·Trends in Neurosciences·S O Meakin, E M Shooter
Jul 5, 1991·Brain Research·M W Wessendorf
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·H NawaP H Patterson
Aug 1, 1990·Trends in Pharmacological Sciences·S Bevan, J Szolcsányi
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J E KrauseA D Hershey
Sep 12, 1989·Nucleic Acids Research·P M BroadR K Craig
Dec 1, 1989·Brain Research. Molecular Brain Research·K NoguchiM Tohyama
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J AllenG Heinrich
Jan 21, 1985·Neuroscience Letters·K ChungR E Coggeshall
Jan 1, 1985·Cell and Tissue Research·D C TaylorJ Szolcsányi
Jun 1, 1971·The Journal of Cell Biology·K M YamadaN K Wessells
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

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Citations

Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert Vink, Corinna van den Heuvel
May 15, 2002·Urology·Francisco Cruz
Jan 13, 2001·Brain Research. Developmental Brain Research·H Kashiba, E Senba
Nov 1, 2001·Brain Research. Molecular Brain Research·H KashibaE Senba
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 6, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·J Lu, M Cwik
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·Chandrasekhar YallampalliSunil J Wimalawansa
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Russell Chess-Williams
Oct 22, 2010·Somatosensory & Motor Research·Tony Mosconi, Theresa Gruber
Aug 11, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·H Kashiba, E Senba
Sep 9, 2006·Current Urology Reports·Humphrey O Atiemo, Sandip P Vasavada
Jan 1, 2013·Brain Sciences·Renée J Turner, Robert Vink
Sep 2, 2021·The Journal of Comparative Neurology·Hayate JavedSafa Shehab

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