Systemic Chemotherapy for Advanced Rare Pancreatic Histotype Tumors: A Retrospective Multicenter Analysis

Pancreas
Oronzo BrunettiNicola Silvestris

Abstract

Two issues were put forth by clinicians in the management of the advanced stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes with peculiar clinical and pathological features: Do chemotherapy regimens recommended in pancreatic ductal adenocarcinoma patients have a clinical activity in rare pancreatic tumors? Or should other chemotherapy combinations be considered in this subset of patients? We conducted a multicenter retrospective study that collected data from 2005 to 2016 at 14 Italian cancer centers with the aim to evaluate tumor response and time to progression for first- and second-line and overall survival. Of approximately 4300 exocrine pancreatic cancer patients, 79 advanced cases affected by rare histological types were identified, with pancreatic acinar cell cancer (n = 23), pancreatic adenosquamous cancer (n = 16), and mucinous cystic neoplasm with an associated invasive mucinous cystadenocarcinoma (n = 15) most represented. Survival analyses for each subgroup in relation with the different chemotherapy regimens showed the lack of statistical significance correlations. Because of the lack of clinical trials in patients affected by these rare pancreatic histotypes, only their mole...Continue Reading

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Citations

Sep 4, 2020·World Journal of Gastrointestinal Oncology·Monica NigerMaria Di Bartolomeo
Aug 28, 2020·Cold Spring Harbor Molecular Case Studies·Elena BuschStefanie Zschäbitz
Dec 29, 2020·World Journal of Gastrointestinal Oncology·Mariacristina Di MarcoRiccardo Casadei
Apr 21, 2020·Diagnostic and Interventional Imaging·R AldhaheriP Soyer
Jul 16, 2021·British Journal of Cancer·Eleonora LaiMario Scartozzi
Dec 1, 2021·Expert Opinion on Therapeutic Targets·Nicola SilvestrisConcetta Saponaro

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