[Systemic clonidine versus opioids in postoperative analgesia-A randomized double-blind study.].

Der Schmerz
M Tryba, M Zenz

Abstract

alpha(2)-Adrenozeptoragonisten agonists have shown antinociceptive and analgesic effects, which are not antagonized by naloxone. Therefore, the mechanism of action should be independent of opioid receptors. Most studies on this topic have been performed using clonidine. Experimentally the analgesic effect of clonidine can be suppressed by the inhibition of central adrenergic receptors. Furthermore, clonidine has analgesic effects at the spinal level. During recent years numerous studies have shown the analgesic effect of spinally or epidurally administered clonidine in humans. However, only very few studies have investigated the analgesic effect of parenterally administered clonidine in humans. After the approval of the local ethical committee had been obtained, 60 patients (ASA I-III, age 18-65 years) scheduled for elective orthopaedic procedures were included in this double-blind randomized study. All patients gave their written consent on the day before the operation. Premedication was standardized and involved benzodiazepines. Isoflurane was used as the sole anaesthetic. Postoperatively the pain level of the patients was controlled by a visual analogue scale (VAS 0-10). When the VAS reached at least 5 and the patients reque...Continue Reading

References

Jul 1, 1977·Clinical and Experimental Pharmacology & Physiology·G A BentleyJ Starr
Jun 1, 1979·British Journal of Anaesthesia·C JordanJ G Jones
Feb 1, 1991·British Journal of Anaesthesia·E J van EssenE J Ploeger
Mar 1, 1990·Anesthesia and Analgesia·G HorváthM Szikszay
Oct 1, 1989·British Journal of Anaesthesia·F BonnetM Ghignone
Nov 1, 1989·Anesthesiology·J C EisenachC M Viscomi
Nov 1, 1989·Anesthesiology·J C EisenachS Z Lysak
May 1, 1985·Pharmacology, Biochemistry, and Behavior·T L Yaksh
May 1, 1986·Acta Anaesthesiologica Scandinavica·J PeterssonL Wiklund
Apr 1, 1987·Anesthesiology·J C EisenachJ M Angelo
Jul 2, 1987·European Journal of Pharmacology·K H Carlsson, I Jurna
Jul 23, 1987·European Journal of Pharmacology·C Advokat, P Burton
May 1, 1970·Life Sciences·N E AndénT Svensson
May 1, 1974·Neuropharmacology·H SchmittN Petillot
Feb 1, 1983·Acta Anaesthesiologica Scandinavica·A RisboJ O Hagelsten
Jan 1, 1980·Journal of Cardiovascular Pharmacology·L Isaac
May 12, 1980·Brain Research·S V Reddy, T L Yaksh
Jan 1, 1981·Medicinal Research Reviews·S Fielding, H Lal
Jan 1, 1981·Journal of Psychiatric Research·B J RounsavilleH D Kleber

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Citations

Aug 6, 1999·Journal of Clinical Pharmacology·H StaunstrupK Krøner
Oct 29, 2004·Clinical Pharmacokinetics·Stefan Grond, Armin Sablotzki
May 23, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D HopkinsJ Murphy
May 15, 2008·Pain Practice : the Official Journal of World Institute of Pain·Luigi Di Lorenzo
Dec 1, 1993·Der Schmerz·H Seemann
May 11, 1999·Cephalalgia : an International Journal of Headache·M SiniatchkinM Hasenbring

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