PMID: 9542596May 30, 1998Paper

Systemic complement depletion reduces inflammation and demyelination in adoptive transfer experimental allergic neuritis

Acta Neuropathologica
F J VriesendorpM A Pappolla

Abstract

The effect of systemic complement depletion by cobra venom factor (CVF) was evaluated in adoptive transfer experimental allergic neuritis (AT-EAN). Spleen cells of rats immunized with a neuritogenic peptide SP26 were injected into naive rats. On days 3 and 6 after cell transfer AT-EAN rats were treated with CVF or saline intraperitoneally. AT-EAN rats treated with CVF had significantly lower scores for histological inflammation (0.25 +/- 0.25 vs 1.9 +/- 0.4, mean +/- SEM, P < 0.03) and demyelination (0.13 +/- 0.13 vs 1.6 +/- 1.4, P < 0.02) than saline-treated AT-EAN rats. Immunocytochemistry of lumbosacral nerve roots showed significantly less ED1-positive macrophages (0.5 +/- 0.3 vs 1.6 +/- 0.6, P < 0.04) and CD11bc-positive (expressing complement receptor 3 or CR3) inflammatory cells (0.6 +/- 0.4 vs 1.7 +/- 0.5, P < 0.03). Our data suggest that complement plays a crucial role in inflammatory demyelination since systemic complement depletion significantly reduces recruitment of macrophages into the nerve and subsequent macrophage-mediated demyelination.

Citations

Jun 25, 2013·Cytokine & Growth Factor Reviews·Hong-Liang ZhangJie Zhu
Mar 10, 2001·Progress in Neurobiology·R KieferH P Hartung
Jan 11, 2011·The Journal of Biological Chemistry·Balasubramanian ManickamNalini S Bora
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