Systemic Contact Dermatitis

Clinical Reviews in Allergy & Immunology
Marcella Aquino, Greg Rosner

Abstract

Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications. Nomenclature remains a challenge as SCD can be subcategorized using terms such as ACDS (allergic contact dermatitis syndrome) and its four clinical stages, Baboon syndrome, and SDRIFE (symmetrical drug-related intertriginous and flexural exanthema), which share many overlapping features. Food allergens may be responsible for uncontrolled or persistent symptoms in patients with contact dermatitis who do not respond to topical a...Continue Reading

References

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Citations

Oct 27, 2018·American Journal of Clinical Dermatology·Patrick M JedlowskiMaryam T Fazel
Apr 13, 2019·Contact Dermatitis·Catarina Alves da Silva, Evy Paulsen
May 8, 2020·International Journal of Dermatology·Joshua SchimmelSteven Manders
Mar 21, 2020·Scientific Reports·Toshinobu KuroishiShunji Sugawara
Mar 1, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Kristin SchmidlinLuz Fonacier
Aug 11, 2019·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ronald M Ferdman
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Feb 16, 2021·American Journal of Clinical Dermatology·Amy E Blum, Susan Burgin
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Apr 15, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Miguel AlpalhãoPaulo Filipe
Jul 16, 2021·Clinical Reviews in Allergy & Immunology·Yan Li, Linfeng Li
Aug 3, 2021·Clinical Reviews in Allergy & Immunology·Zhouxian PanJing Zhang
Aug 21, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot
Dec 24, 2021·Contact Dermatitis·Rohit KothariSatish Chand

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