Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Daisuke AkagiMichael S Conte

Abstract

Vascular injury induces a potent inflammatory response that influences vessel remodeling and patency, limiting long-term benefits of cardiovascular interventions such as angioplasty. Specialized proresolving lipid mediators (SPMs) derived from ω-3 polyunsaturated fatty acids [eicosapentaenoic acid and docosahexaenoic acid (DHA)] orchestrate resolution in diverse settings of acute inflammation. We hypothesized that systemic administration of DHA-derived SPMs [resolvin D2 (RvD2) and maresin 1 (MaR1)] would influence vessel remodeling in a mouse model of arterial neointima formation (carotid ligation). In vitro, SPM treatment inhibited mouse aortic smooth muscle cell migration (IC₅₀ ≅ 1 nM) to a PDGF gradient and reduced TNF-α-stimulated p65 translocation, superoxide production, and proinflammatory gene expression (MCP-1). In vivo, adult FVB mice underwent unilateral carotid artery ligation with administration of RvD2, MaR1, or vehicle (100 ng by intraperitoneal injection at 0, 1, 3, 5, and 7 d after ligation). In ligated carotid arteries at 4 d, SPM treatment was associated with reduced cell proliferation and neutrophil and macrophage recruitment and increased polarization of M2 macrophages in the arterial wall. Neointimal hyperp...Continue Reading

References

Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·M W CarrT A Springer
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A Kumar, V Lindner
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jan 28, 2004·Circulation·Jaikirshan J KhatriZorina S Galis
Nov 19, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Vyacheslav A KorshunovBradford C Berk
Jun 19, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aksam J MerchedLawrence Chan
Jul 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Karen J HoMichael S Conte
Dec 24, 2008·The Journal of Experimental Medicine·Charles N SerhanMatthew Spite
May 16, 2009·Expert Opinion on Therapeutic Patents·Mingde Xia, Zhihua Sui
Aug 18, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Douglas NamHanjoong Jo
Jun 30, 2011·The Biochemical Journal·Gabrielle Fredman, Charles N Serhan
Jul 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allisson Freire BentoJoão B Calixto
Oct 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esther TitosJoan Clària
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanNicos A Petasis
Nov 1, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stefan BohrFrancois Berthiaume
Feb 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya MiyaharaMichael S Conte
Feb 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tomohiro KuriharaDaniel Irimia
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Jun 14, 2013·ISRN Minimally Invasive Surgery·Andrew W Holt, David A Tulis
Sep 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodrigo MarconJoão B Calixto
Nov 28, 2013·Journal of the American Heart Association·Douglas W JonesUNKNOWN Vascular Study Group of New England
Feb 15, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J P SteffensT E Van Dyke
Mar 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masanori KatakuraOsamu Shido
Mar 29, 2014·Cardiovascular Research·Katsuhito FujiuRyozo Nagai
Apr 5, 2014·British Journal of Pharmacology·Jie GongYou Shang
Jun 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurie K McCauleyCharles N Serhan

❮ Previous
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Citations

May 7, 2015·Journal of Molecular and Cellular Cardiology·Kirkwood A Pritchard, Dorothee Weihrauch
Sep 24, 2015·IUBMB Life·Rachel Marion-LetellierSubrata Ghosh
Aug 11, 2016·Journal of Biomedical Materials Research. Part a·Kevin D LanceMichael S Conte
Mar 5, 2017·Molecular Aspects of Medicine·Gabrielle Fredman, Matthew Spite
Mar 1, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nan ChiangCharles N Serhan
Aug 11, 2016·Circulation·Michael J ZhangMatthew Spite
Aug 18, 2016·Circulation Research·Joana R ViolaOliver Soehnlein
Dec 26, 2018·Expert Review of Cardiovascular Therapy·Mohan Satish, Devendra K Agrawal
Jul 4, 2019·Clinical Reviews in Allergy & Immunology·Fereshte AbdolmalekiAmirhossein Sahebkar
Sep 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicolas H PopeGilbert R Upchurch
Apr 29, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tarec K ElajamiFrancine K Welty
Apr 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anuran ChatterjeeMichael S Conte
Dec 22, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Lucy V NorlingJesmond Dalli
Aug 21, 2018·Frontiers in Cardiovascular Medicine·Julius L Decano, Masanori Aikawa
Sep 1, 2018·The Journal of Clinical Investigation·Michael S ConteEvan Werlin
Nov 30, 2018·Frontiers in Pharmacology·John Pirault, Magnus Bäck
Jan 13, 2017·Journal of Thrombosis and Haemostasis : JTH·K L LannanR P Phipps
Mar 9, 2019·Nature Reviews. Cardiology·Magnus BäckPetri T Kovanen
May 10, 2020·Journal of Dental Research·C W WangW V Giannobile
Jul 19, 2019·Oxidative Medicine and Cellular Longevity·Alessandro LeutiValerio Chiurchiù
Jul 9, 2020·Frontiers in Immunology·Aslıhan Avanoǧlu GülerMarco Matucci-Cerinic
Oct 21, 2020·International Journal of Molecular Sciences·Nikola TułowieckaMałgorzata Szczuko
Dec 1, 2020·Frontiers in Aging Neuroscience·Ying ZhouMian Peng
Mar 11, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Hanna RuhanenVesa M Olkkonen
Feb 23, 2021·Frontiers in Immunology·Yu SawadaMotonobu Nakamura
Nov 25, 2018·Journal of Vascular Surgery·Michael SpinosaGilbert R Upchurch
Jul 31, 2020·Advanced Drug Delivery Reviews·Josefin SoppertHeidi Noels
Aug 11, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Hanna RuhanenVesa M Olkkonen
Jul 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Craig T ElderGilbert R Upchurch

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