Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12

The Journal of Steroid Biochemistry and Molecular Biology
Nobuyuki SakuraiHiroshi Handa

Abstract

The 17beta-hydroxysteroid dehydrogenases (HSDs) are enzymes that catalyze the reduction of 17-ketosteroids or the oxidation of 17beta-hydroxysteroids. 17beta-HSD type 12, the most recently cloned member of this gene family, was classified into the 17beta-HSD family based on sequence homology, rather than steroid catalyzing activity. Meanwhile, it has been reported that 17beta-HSD type 12 may be involved in fatty acid synthesis. To better understand the role of 17beta-HSD type 12 in lipid metabolism, we determined the detailed systemic distribution and tissue localizations of 17beta-HSD type 12, which, due partly to the lack of antibodies, had not yet been studied. We carried out these investigations by quantitative reverse transcription (RT)-PCR, Northern blot analysis, and immunohistochemistry, using an antibody against 17beta-HSD type 12 that we have generated. 17beta-HSD type 12 is highly expressed in organs related to lipid metabolism such as liver, kidney, heart and skeletal muscle. 17beta-HSD type 12 is also detected in endocrine-related organs such as pancreas, pituitary gland, adrenal gland, testis and placenta, and in the gastrointestinal tract, which point to the possible involvement of 17beta-HSD type 12 in the regul...Continue Reading

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Citations

Mar 1, 2012·Journal of Physiology and Biochemistry·Mirja RotinenIgnacio Encío
Feb 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Jianguo LiuDandan Yang
Jul 22, 2010·Expert Opinion on Therapeutic Patents·Donald Poirier
Oct 17, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Daniela LimaL Filipe C Castro
Jun 29, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Martin HillLuboslav Stárka
Nov 26, 2008·Molecular and Cellular Endocrinology·Gabriele Moeller, Jerzy Adamski
Jun 17, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Tadashi OgishimaMakoto Suematsu
Jun 18, 2009·Molecular and Cellular Endocrinology·Shuji NagasakiHironobu Sasano
Jan 10, 2008·International Journal of Cancer. Journal International Du Cancer·Joanna M DayAtul Purohit
Mar 3, 2009·Annals of the New York Academy of Sciences·Shuji NagasakiHironobu Sasano
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·André TchernofVan Luu-The
Feb 26, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Andrzej SlominskiRobert C Tuckey
Oct 21, 2016·Reviews in Endocrine & Metabolic Disorders·Georgios NikolakisChristos C Zouboulis
Jul 14, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Masahisa Nakamura
Jun 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diane RebourcetLee B Smith
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Aug 8, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Shuji OhnoShizuo Nakajin
Jun 10, 2014·ACS Chemical Biology·Alexandre TrottierDonald Poirier

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