Systemic drug reactions with skin involvement: Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS

Clinics in Dermatology
Razvigor DarlenskiNikolai Tsankov

Abstract

Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement.

References

May 29, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·S Tas, T Simonart
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Tetsuo ShioharaYoko Kano
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Lars E French
Jun 15, 2010·Clinics in Dermatology·Ronni Wolf, Batya Davidovici
Apr 13, 2011·British Journal of Clinical Pharmacology·Bernard Y-H Thong, Teck-Choon Tan
Oct 22, 2011·Expert Review of Clinical Immunology·Maja Mockenhaupt
Oct 22, 2011·Clinics in Dermatology·Carol E Cheng, Daniela Kroshinsky
Jun 19, 2012·The Korean Journal of Internal Medicine·Hye-In KimNeung-Su Kim
Dec 1, 2011·The Journal of the American College of Clinical Wound Specialists·Rose L Hamm

❮ Previous
Next ❯

Citations

Feb 6, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ariana EginliGuha Krishnaswamy
Jul 1, 2017·Pediatric Emergency Care·Howard M Corneli
Mar 11, 2016·Clinical Pediatrics·Thomas P WolskiMartha G Blackford
May 31, 2020·Dermatologic Therapy·Dilek MenteşoğluSibel Ersoy-Evans
Jul 1, 2020·The Journal of Craniofacial Surgery·Bruno Coelho MendesJoão Paulo Bonardi
Dec 12, 2018·Drug Safety - Case Reports·Josiah Tatenda MasukaDixon Chibanda
Sep 4, 2021·Research in Social & Administrative Pharmacy : RSAP·Meagan HayashiSherif Hanafy Mahmoud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.