Systemic efficacy of nodulisporic acid against fleas on dogs

The Journal of Parasitology
W L ShoopD M Schmatz

Abstract

Nodulisporic acid A (NSA) is a novel natural product from a new structural class that was shown previously to have insecticidal activity against blowfly larvae. To determine if there was useful systemic efficacy against fleas (Ctenocephalides felis). NSA was evaluated in an artificial membrane flea feeding device and in dogs. In the artificial membrane flea feeding device, adult C. felis were allowed to feed on bovine blood containing various concentrations of NSA through a Parafilm membrane. NSA killed the fleas with a 50% lethal concentration of 0.68 microg/ml and was approximately 10-fold more potent than the systemic insecticide ivermectin. In the initial probe dog test, a single beagle was challenged with 100 C. felis before oral dosing with 15 mg/kg of NSA. Flea counts conducted at 72 hr postdosing showed an 88% reduction relative to control. Re-challenge of the same dog at 5 days postdosing showed 50% reduction of fleas at day 7, demonstrating some residual flea activity. In a confirmatory study, 8 dogs were challenged with 100 fleas just before oral dosing with 15 mg/kg of NSA (4 dogs) or vehicle (4 dogs). There was 99% reduction of fleas at 48 hr postdosing in the NSA-treated dogs relative to control. Additional challe...Continue Reading

References

Nov 1, 1995·Veterinary Parasitology·M ZaksonW L Shoop
Jan 16, 1998·Medical and Veterinary Entomology·D A OstlindW Mickle
Oct 31, 2000·Bioorganic & Medicinal Chemistry Letters·P T MeinkeM H Fisher

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Citations

Oct 31, 2000·Bioorganic & Medicinal Chemistry Letters·P T MeinkeM H Fisher
Jul 31, 2001·Journal of Medical Entomology·M Zakson-AikenW L Shoop
Aug 28, 2014·Critical Reviews in Microbiology·Monika Sharma, Rohit Sharma
Nov 9, 2001·Organic Letters·R BergerS L Colletti
Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·John G OndeykaSheo B Singh
Jan 13, 2018·Genome Announcements·Matthew J NicholsonEmily J Parker
Sep 18, 2018·Natural Product Research·Jia-Hao LiangYi-Xuan Zhang
Nov 7, 2001·The Journal of Parasitology·W L ShoopD M Schmatz
Feb 19, 2021·Accounts of Chemical Research·William P Thomas, Sergey V Pronin
Jul 22, 2018·Journal of the American Chemical Society·Yike ZouAmos B Smith

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Methods Mentioned

BETA
gel filtration

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