Systemic fluoroquinolone prescriptions for hospitalized children in Belgium, results of a multicenter retrospective drug utilization study

BMC Infectious Diseases
Kevin MeestersPauline De Bruyne

Abstract

Fluoroquinolones (FQ) are increasingly prescribed for children, despite being labeled for only a limited number of labeled pediatric indications. In this multicenter retrospective drug utilization study, we analyzed indications for systemic FQ prescriptions in hospitalized children and the appropriateness of the prescribed dose. Using data obtained from electronic medical files, the study included all children who received a systemic FQ prescription in two Belgian university children's hospitals between 2010 and 2013. Two authors reviewed prescribed daily doses. Univariate and multivariate logistic regression models were used to analyze risk factors for inadequately dosing. Results262 FQ prescriptions for individual patients were included for analysis. 16.8% of these prescriptions were for labeled indications, and 35.1% were guided by bacteriological findings. Prescribed daily dose was considered to be inappropriate in 79 prescriptions (30.2%). Other FQ than ciprofloxacin accounted for 9 prescriptions (3.4%), of which 8 were correctly dosed. Underdosing represented 45 (56.9%) dosing errors. Infants and preschool children were at particular risk for dosing errors, with associated adjusted OR of 0.263 (0.097-0.701) and 0.254 (0.1...Continue Reading

References

Nov 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D A LinsemanD G Branstetter
Jan 1, 1996·Archives of Toxicology·C FörsterR Stahlmann
Apr 29, 1998·Diagnostic Microbiology and Infectious Disease·J EnaI Ruíz-López
May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·K YoshidaK Furuhama
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J LipmanS C Wallis
Sep 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P G ScottonM Furlanut
Apr 2, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F DaxboeckC Wenisch
Apr 12, 2003·The Pediatric Infectious Disease Journal·Elio CastagnolaUNKNOWN Infectious Diseases Study Group of the Italian Association of Pediatric Hematology and Oncology
Sep 5, 2003·The Lancet Infectious Diseases·Dominique GendrelJosette Raymond
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Christian JoukhadarMarkus Müller
Sep 5, 2006·Pediatrics·UNKNOWN Committee on Infectious Diseases
Aug 3, 2007·Pediatrics·Laura J ChristieCarol A Glaser
Oct 17, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H ImranV M Montori
Aug 29, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W C AlffenaarT S van der Werf
Jun 30, 2010·Archives of Disease in Childhood. Education and Practice Edition·H Mulla, T N Johnson
Jul 26, 2011·Archives of Disease in Childhood·Abiodun AdefurinImti Choonara
Nov 22, 2011·Pediatric Blood & Cancer·Sarah AlexanderLillian Sung
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Dec 18, 2012·The Pediatric Infectious Disease Journal·Waheeb SakranYosef Uziel
May 29, 2013·BMC Infectious Diseases·Zhi-Tao YangOlivier Lortholary
Feb 26, 2014·Pediatrics·Daniel A FrattarelliUNKNOWN American Academy of Pediatrics Committee on Drugs
Jun 20, 2014·PLoS Pathogens·Patrick M Meyer SauteurAnnemarie M C van Rossum
Aug 28, 2014·International Journal of Clinical Pharmacology and Therapeutics·Mathieu GenuiniMathie Lorrot
Mar 13, 2015·The Pediatric Infectious Disease Journal·Susanna FelsensteinJill A Hoffman
Mar 24, 2015·Tuberculosis·S TheeH S Schaaf
Jul 22, 2015·Antimicrobial Agents and Chemotherapy·Anthony J Garcia-PratsAnneke C Hesseling
Sep 10, 2015·Antimicrobial Agents and Chemotherapy·Pieter A J G De CockPeter De Paepe
Feb 13, 2016·Journal of Clinical Pharmacology·Karisma Patel, Jennifer L Goldman
Jul 26, 2016·Frontiers in Microbiology·Sabine PereyreCécile Bébéar
Aug 20, 2016·BMC Infectious Diseases·Nicola Principi, Susanna Esposito
Nov 2, 2016·Archives of Disease in Childhood·Tjitske M van der ZandenUNKNOWN Dutch Paediatric Pharmacotherapy Expertise Network NKFK (Nederlands Kenniscentrum voor Farmacotherapie bij Kinderen)
Dec 13, 2016·Pediatrics·Mary Anne JacksonUNKNOWN COMMITTEE ON INFECTIOUS DISEASES
Jan 13, 2017·Pharmacotherapy·Stephanie NataleJennifer Le

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Research in Pharmacy Practice
Toktam FaghihiKheirollah Gholami
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
A Pariente-KhayatGérard Pons
International Journal of Clinical Pharmacology and Therapeutics
Mathieu GenuiniMathie Lorrot
© 2022 Meta ULC. All rights reserved