Systemic GLP-2 levels do not limit adaptation after distal intestinal resection

Journal of Pediatric Surgery
D TopstadD L Sigalet

Abstract

Glucagonlike peptide 2 (GLP-2) is trophic for the small bowel; it is produced by L cells in the distal intestine in response to luminal nutrients. This study tests the hypothesis that distal small bowel and cecal resection would decrease GLP-2 levels and reduce adaptation. Male Sprague-Dawley rats (200 to 300 g) underwent either ileal transection (controls) or resection of the ileum and cecum, leaving 10 or 20 cm jejunal remnant anastomosed to the ascending colon. Animals were followed up for up to 21 days. Endpoints were daily weights, intestinal histology, in vivo absorption of 3-0 methylglucose (a measurement of active nutrient absorptive capacity), and serum GLP-2 levels. The control group had a maximum 6% weight loss around day 2, and then recovered with a steady weight gain. The 10-cm jejunal remnant group lost weight continuously and never recovered postsurgery. The 20-cm jejunal remnant group of animals had a maximum of 12% weight loss by day 4 and then slowly gained weight. The average villus height increased significantly (P <.01) in the 10-cm and 20-cm jejunal remnant groups compared with controls. Absorption of 3-0 methylglucose was significantly decreased (P <.01) in both resected groups. Serum GLP-2 levels were in...Continue Reading

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Citations

May 27, 2006·Journal of Gastroenterology and Hepatology·Prue M Pereira, Julie E Bines
Apr 11, 2006·Annual Review of Nutrition·Jennifer L Estall, Daniel J Drucker
Dec 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Junqiang TianThomas R Ziegler
Jan 20, 2009·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
Feb 21, 2009·World Journal of Gastroenterology : WJG·Laurie A DrozdowskiAlan B R Thomson
Jan 27, 2016·Expert Opinion on Therapeutic Targets·David W LimPatricia L Brubaker
Sep 15, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Hideki YoshikawaYoshikatsu Eto
Feb 14, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gary R MartinDavid L Sigalet
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Olivier GouletVirginie Colomb
Jun 18, 2004·Pediatric Research·David L SigaletJens J Holst
Aug 24, 2006·Digestive Diseases and Sciences·D L SigaletA Zubaidi
Mar 4, 2008·Journal of Autism and Developmental Disorders·Marli A RobertsonKeith A Sharkey
Dec 29, 2007·Journal of Pediatric Gastroenterology and Nutrition·Prue M Pereira-FantiniJulie E Bines
Oct 13, 2006·Current Opinion in Gastroenterology·Julian R F Walters
Aug 29, 2006·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson

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