Systemic glycerol decreases neonatal rabbit brain and cerebellar growth independent of intraventricular hemorrhage

Pediatric Research
Christopher M TraudtSandra E Juul

Abstract

Cerebellar hypoplasia is a common problem in preterm infants and infants suffering from intraventricular hemorrhage (IVH). To evaluate the effects of IVH on cerebellar growth and development, we used a neonatal rabbit model of systemic glycerol to produce IVH. New Zealand White rabbit kits were surgically delivered 2 d preterm and treated with intraperitoneal glycerol (3.25-6.5 g/kg). Controls were born at term. IVH was documented by ultrasonography. Brain volumes determined by magnetic resonance imaging, cerebellar foliation, proliferation (Ki-67), and Purkinje cell density were assessed at 2 wk of life. Tissue glycerol and glutathione concentrations were measured. Glycerol increased IVH, subarachnoid hemorrhages, and mortality in a dose-dependent manner. Total cerebellar volumes, cerebellar foliation, and cerebellar proliferation were decreased in a dose-dependent manner. Glycerol accumulated rapidly in blood, brain, and liver and was associated with increased glutathione concentration. All of these results were independent of IVH status. Cerebellar hypoplasia was induced after glycerol administration in a dose-dependent manner. Given the rapid tissue accumulation of glycerol, dose-dependent decrease in brain growth, and lack...Continue Reading

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Citations

Aug 12, 2014·Pediatric Research·Christopher M Traudt, Sandra E Juul
Jun 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kristen EmpieSandra E Juul
Mar 4, 2017·European Journal of Nutrition·Alejo M CapiglioniMaría de Luján Alvarez
Nov 12, 2020·International Journal of Molecular Sciences·Isabel Atienza-NavarroMonica Garcia-Alloza
Mar 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joanna A RuszkiewiczMichael Aschner
Jun 27, 2021·Journal of Neuroscience Research·Zhongjie ShiSidhartha Tan

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