Systemic haemodynamics of dihydropyridine derivatives in conscious pigs with or without propranolol

European Journal of Pharmacology
D J DunckerP D Verdouw

Abstract

The systemic haemodynamic effects of a 10 min i.v. infusion of three dihydropyridine Ca2+ channel blockers, nifedipine (1, 2 and 4 micrograms.kg-1.min-1), nisoldipine (0.5, 1 and 2 micrograms.kg-1.min-1) and nimodipine (1, 2 and 4 micrograms.kg-1.min-1) were studied in instrumented conscious pigs with or without a propranolol-induced beta-adrenoceptor blockade (0.5 mg.kg-1 bolus followed by 0.5 mg.kg-1.h-1). Initial experiments showed that the solvent used for the Ca2+ channel blockers had no haemodynamic effects and that the effects of propranolol wer constant during a 30 min period. Nisoldipine, nimodipine and nifedipine elicited qualitatively similar effects, causing a dose-dependent decrease in blood pressure and systemic vascular resistance. These effects were accompanied by a reflex-mediated increase in heart rate, cardiac output and left ventricular rate of rise in pressure (LVdP/dtmax). Nisoldipine was about 2-3 times more potent than the other two drugs. Propranolol did not modify the vasodilation induced by the Ca2+ channel blockers but attenuated the increase in heart rate, cardiac output and LVdP/dtmax. In view of the reflex-tachycardia and the absence of negative inotropic actions, these Ca2+ channel blockers can b...Continue Reading

References

Jul 1, 1985·Journal of Cardiovascular Pharmacology·K C PreussD C Warltier
Sep 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·P D VerdouwP R Saxena
Oct 1, 1981·The American Journal of Medicine·H J DargieS Krikler
Aug 25, 2005·Clinical Physiology and Functional Imaging·Michal JavorkaKamil Javorka

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Citations

Nov 1, 1990·British Journal of Pharmacology·L M SassenP D Verdouw
Jun 1, 1990·British Journal of Pharmacology·W J van der GiessenP D Verdouw
Jul 29, 1998·The Journal of Pharmacy and Pharmacology·H C Champion, P J Kadowitz
May 1, 1992·The American Journal of Cardiology·H SuryapranataP W Serruys
Jun 1, 1994·Current Eye Research·K GreenD S Hull
Aug 1, 1996·Journal of Cardiovascular Pharmacology·D Karila-CohenA Berdeaux
Oct 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Marc J van HouwelingenDirk J Duncker

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