Systemic hemodynamics in non-anesthetized L-NAME- and DOCA-salt-treated mice

Journal of Hypertension
Michael ObstFriedrich C Luft

Abstract

Long-term cardiac output measurements in non-anesthetized mice are now possible. We used this technology to study two different hypertensive models in mice. We combined telemetric blood pressure and heart rate recordings with Doppler flow probe cardiac output measurements in mice during treatment with Nomega-nitro-L-arginine methyl ester (L-NAME) and deoxycorticosterone acetate (DOCA)-salt. The mice received a flowprobe around the ascending aorta and, 10-18 days later, blood pressure telemetry. After recovery, baseline values were recorded and the mice were given L-NAME (5 mg/10 ml tap water), L-NAME followed by valsartan (50 mg/kg per day per gavage), or DOCA-salt (50 mg DOCA-pellet, 0.9% saline to drink, uninephrectomy). Mean arterial pressure, heart rate, stroke volume and cardiac output were recorded daily and total peripheral resistance was calculated. L-NAME resulted in an abrupt increase in mean arterial pressure caused solely by an increase in total peripheral resistance. Cardiac output was decreased. Valsartan treatment decreased blood pressure and total peripheral resistance, while cardiac output was restored to normotensive values. DOCA-salt required 3 days before hypertension developed. Contrary to the volume expans...Continue Reading

References

Nov 1, 1979·Hypertension·A W MillerJ M Terris
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J P MontaniA C Guyton
Jun 1, 1988·Hypertension·C Hinojosa-LabordeA W Cowley
Jan 1, 1984·Journal of Cardiovascular Pharmacology·A C GuytonY J Pan
Nov 14, 1997·Kidney International·V GrossF C Luft
Dec 24, 1997·British Journal of Pharmacology·C T HuH I Chen
Nov 20, 1998·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C HablyJ Bartha
Nov 24, 1999·The American Journal of Physiology·T YangA K Mircheff
Oct 3, 2000·The American Journal of the Medical Sciences·J VaragicD Kentera
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M YuJ R McNeill
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B JanssenJ Smits
Mar 14, 2002·Seminars in Nephrology·Volkmar Gross, Friedrich C Luft
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ben J A Janssen, Jos F M Smits
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John N Lorenz
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Michael ObstFriedrich C Luft

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Citations

Mar 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueAlan Kim Johnson
Nov 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael ObstVolkmar Gross
Jan 20, 2010·Circulation·Gad A SilbermanSamuel C Dudley
Nov 1, 2008·Journal of the American Society of Hypertension : JASH·Andrey Ch da Costa GoncalvesVolkmar Gross
Nov 28, 2012·Hypertension·Vera Regitz-ZagrosekDuska Dragun
Oct 1, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leonhard SchäfferHugo H Marti
Jul 24, 2007·Experimental Physiology·Hantz C HerculeVolkmar Gross
Feb 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Zhila TaherzadehErik N T P Bakker
Nov 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ryuji HataishiFumito Ichinose
Aug 12, 2009·Molecular Biology Reports·Behjat SeifiManoocher Soleimani
Jun 14, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John P CollisterJohn W Osborn
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Young Hee KimSusan M Wall
May 16, 2017·Kidney International·Jens Titze, Friedrich C Luft

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