Systemic hernial disease protects against cancer: an hypothesis.

Hernia : the Journal of Hernias and Abdominal Wall Surgery
R C Read

Abstract

Research by herniologists from around the world has shown that abdominal defects, in the adult, are not caused by wear and tear but systemic hernial disease (herniosis), a disorder of connective tissue which affects the extracellular matrix (ECM). Wound healing may be affected, leading to recurrences after hernia repair or primary incisional herniation. Women with genitourinary prolapse show signs of herniosis in the pelvis. Diverticulosis coli, commonly seen in the elderly, like hernia, was once attributed to stress and strain from constipation. It is now suspected that herniosis weakens the colonic ECM, allowing the mucosa to form diverticula by herniating alongside the vasa recta. Remarkably, clinical studies of Saint's triad extending over the past 60 years have repeatedly demonstrated a highly significant relationship between colonic diverticula and abdominal herniae. Krones et al. (Int J Colorectal Dis 21:18-24, 2006) reported that diverticula and cancer are rarely coincident in the colon, despite aging. Their data indicate that the two pathologies arise in different ECMs. Klinge et al. (Int J Colorectal Dis 22:515-520, 2007), quoting Paget (Lancet 1:571-573, 1889), "Tumor cells can like seeds only grow if they fall on co...Continue Reading

References

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Aug 5, 2004·Hernia : the Journal of Hernias and Abdominal Wall Surgery·U KlingeP R Mertens
May 13, 2005·International Journal of Colorectal Disease·C J KronesV Schumpelick
Oct 6, 2006·International Journal of Colorectal Disease·U KlingeV Schumpelick
Nov 3, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Michael StumpfVolker Schumpelick
May 18, 2007·Hernia : the Journal of Hernias and Abdominal Wall Surgery·R C Read
Apr 17, 2008·Hernia : the Journal of Hernias and Abdominal Wall Surgery·R C Read
Jun 19, 2008·British Journal of Hospital Medicine·G P ThomasA Darzi
Jun 27, 2008·Journal of Clinical Gastroenterology·Sergio MoriniSalvatore M A Campo
Aug 16, 2008·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M Hauer-JensenR C Read

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Citations

Jun 15, 2010·Hernia : the Journal of Hernias and Abdominal Wall Surgery·L Filik, I Biyikoglu
May 19, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·R C Read
Jan 5, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Levent Filik
Apr 27, 2019·Frontiers in Surgery·Hakan Kulacoglu, Ferdinand Köckerling

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