Systemic High-Mobility Group Box-1: A Novel Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage

Critical Care Medicine
Shafqat R ChaudhrySajjad Muhammad

Abstract

To investigate the release of proinflammatory damage-associated molecular pattern molecule "high-mobility group box-1" in the serum of patients after aneurysmal subarachnoid hemorrhage and its association with cerebral vasospasm. Retrospective observational study. University hospital. Aneurysmal subarachnoid hemorrhage patients admitted within 24 hours of ictus. Standard subarachnoid hemorrhage treatment after clipping or coiling of aneurysm. We enrolled 53 aneurysmal subarachnoid hemorrhage patients from which peripheral venous blood was withdrawn on days 1, 3, 5, 7, 9, 11, and 13 and once from the controls to obtain the serum. Serum high-mobility group box-1 concentration was quantified by enzyme-linked immunosorbent assay. Serum interleukin-6 and peripheral blood leukocytes were also determined over the first 2 weeks after subarachnoid hemorrhage. Patients' data were recorded prospectively. Serum high-mobility group box-1 was significantly elevated in subarachnoid hemorrhage patients from day 1 to day 13 when compared with nonsubarachnoid hemorrhage patients (p < 0.05). Patients with cerebral vasospasm showed significantly higher high-mobility group box-1 starting from day 1 to day 13 when compared with patients without cere...Continue Reading

References

Jul 10, 1999·Science·H WangK J Tracey
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beatriz Rendon-MitchellHaichao Wang
Oct 22, 2003·Brain Research·Hitoshi KimuraJohn H Zhang
Jan 27, 2006·The New England Journal of Medicine·Jose I SuarezWarren R Selman
Jan 30, 2007·Lancet·Jan van GijnGabriel J E Rinkel
Apr 5, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M-L ZhouH-X Yin
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jianhua QiuMichael A Moskowitz
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sajjad MuhammadMarkus Schwaninger
Sep 25, 2009·Neurocritical Care·Takashi NakaharaTsuyoshi Maekawa
Jan 12, 2011·Annual Review of Immunology·Ulf Andersson, Kevin J Tracey
Feb 5, 2011·Stroke; a Journal of Cerebral Circulation·Sajjad MuhammadMarkus Schwaninger
Feb 26, 2011·Stroke; a Journal of Cerebral Circulation·R Webster CrowleyR Loch Macdonald
Feb 2, 2012·Nature Reviews. Rheumatology·Helena Erlandsson HarrisDavid S Pisetsky
Feb 7, 2012·Neuroscience Letters·Victor FriedrichFatima A Sehba
Apr 21, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yong JiangJian-Guo Shi
Aug 25, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Sherry H-Y ChouMingMing Ning
Sep 7, 2012·Journal of Neurointerventional Surgery·Catherine J McMahonPippa J Tyrrell
Nov 1, 2012·World Neurosurgery·Albert J Schuette, Daniel L Barrow

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Citations

Jun 11, 2020·Journal of Clinical Medicine·Baptiste BalançaFrédéric Dailler
Apr 17, 2020·International Journal of Molecular Sciences·Sajjad MuhammadDaniel Hänggi
Dec 7, 2019·Cellular and Molecular Neurobiology·Kevin Min Wei KheySherif Hanafy Mahmoud
Jul 3, 2020·International Journal of Molecular Sciences·Yam Nath PaudelMohd Farooq Shaikh
Oct 23, 2019·Antioxidants·Sandra KaiserNils Schallner
May 1, 2021·International Journal of Molecular Sciences·Matthias Simon, Alexander Grote
May 1, 2021·International Journal of Molecular Sciences·Hammad AhmedSajjad Muhammad
Jun 3, 2021·International Journal of Molecular Sciences·Judith WeilandNadine Lilla
Jul 25, 2021·International Journal of Molecular Sciences·Sajjad Muhammad, Daniel Hänggi

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